The interplay between surface nanotopography and chemistry modulates collagen I and III deposition by human dermal fibroblasts

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dc.contributor.authorBachhuka, A.
dc.contributor.authorHayball, J.
dc.contributor.authorSmith, L.
dc.contributor.authorVasilev, K.
dc.date.issued2017
dc.description.abstractThe events within the foreign body response are similar to, but ultimately different than, the wound healing cascade. Collagen production by fibroblasts is known to play a vital role in wound healing and device fibrous encapsulation. However, the influence of surface nanotopography on collagen deposition by these cells has not been reported so far. To address this gap, we have developed model substrata having surface nanotopography of controlled height of 16, 38, and 68 nm and tailored outermost surface chemistry of amines, carboxyl acid, and pure hydrocarbon. Fibroblast adhesion was reduced on nanotopographically modified surfaces compared to the smooth control. Furthermore, amine and acid functionalized surfaces showed increased cell proliferation over hydrophobic hydrocarbon surfaces. Collagen III production increased from day 3 to day 8 and then decreased from day 8 to day 16 on all surfaces, while collagen I deposition increased throughout the duration of 16 days. Our data show that the initial collagen I and III deposition can be modulated by selecting desired combinations of surface nanotopography and chemistry. This study provides useful knowledge that could help in tuning fibrous capsule formation and in turn govern the fate of implantable biomaterial devices.
dc.description.statementofresponsibilityAkash Bachhuka, John Dominic Hayball, Louise E. Smith and Krasimir Vasilev
dc.identifier.citationACS Applied Materials and Interfaces, 2017; 9(7):5874-5884
dc.identifier.doi10.1021/acsami.6b15932
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.orcidBachhuka, A. [0000-0003-1253-8126]
dc.identifier.orcidHayball, J. [0000-0002-3089-4506]
dc.identifier.urihttp://hdl.handle.net/2440/105260
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.granthttp://purl.org/au-research/grants/arc/DP150104212
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1122825
dc.rightsCopyright © 2017 American Chemical Society
dc.source.urihttps://doi.org/10.1021/acsami.6b15932
dc.subjectBiomaterials
dc.subjectcollagens I and III
dc.subjectforeign body response
dc.subjectplasma polymerization
dc.subjectsurface nanotopography
dc.titleThe interplay between surface nanotopography and chemistry modulates collagen I and III deposition by human dermal fibroblasts
dc.typeJournal article
pubs.publication-statusPublished

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