Mesenchymal stem cell-mediated functional tooth regeneration in swine
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(Published version)
Date
2006
Authors
Sonoyama, W.
Liu, Y.
Fang, D.
Yamaza, T.
Seo, B.
Zhang, C.
Liu, H.
Gronthos, S.
Wang, C.
Shi, S.
Editors
Csete, M.
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Journal article
Citation
PLoS One, 2006; Dec 2006(1):e79-
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Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung-Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun-Yu Wang,Songtao Shi and Songlin Wang
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Abstract
Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.
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Copyright 2006 Sonoyama et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.