Intraduodenal protein modulates antropyloroduodenal motility, hormone release, glycemia, appetite, and energy intake in lean men

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dc.contributor.authorHutchison, A.
dc.contributor.authorFeinle-Bisset, C.
dc.contributor.authorKallas, A.
dc.contributor.authorWishart, J.
dc.contributor.authorClifton, P.
dc.contributor.authorHorowitz, M.
dc.contributor.authorLuscombe-Marsh, N.
dc.date.issued2012
dc.description.abstractBACKGROUND: Intraduodenal fat and carbohydrate modulate antropyloroduodenal motility and hormone release and suppress appetite and energy intake in a load-dependent manner. Protein also suppresses energy intake, but its effects on these gastrointestinal factors and their role in the appetite-suppressive effects of protein remain unclear. OBJECTIVE: We aimed to characterize the effects of different intraduodenal protein loads on antropyloroduodenal pressures, gastrointestinal hormone release, glucose and insulin concentrations, appetite perceptions, and energy intake. DESIGN: Sixteen lean, healthy men were studied on 4 occasions in a randomized, double-blind fashion. Antropyloroduodenal pressures, plasma glucagon-like peptide 1 (GLP-1), cholecystokinin, peptide YY, ghrelin, blood glucose, serum insulin, and appetite were measured during 60-min, 4-mL/min intraduodenal infusions of protein at 0.5, 1.5, or 3 kcal/min or saline (control). Energy intakes at a buffet lunch consumed immediately after the infusion were quantified. RESULTS: Increases in the load of protein resulted in greater suppression of antral motility, greater stimulation of basal and isolated pyloric pressures and plasma cholecystokinin and GLP-1 concentrations, and greater suppression of energy intake. However, energy intake was reduced only after a protein load of 3 kcal/min compared with after all other treatments (P< 0.05). The suppression of energy intake after adjustment for cholecystokinin, GLP-1, and insulin was related inversely with basal pyloric pressure (r = 20.51, P < 0.001). CONCLUSION: The acute effects of intraduodenal protein on antropyloroduodenal motility, gastrointestinal hormone release, glucose, and insulin are load dependent and contribute to the suppression of energy intake.
dc.description.statementofresponsibilityAmy T. Ryan, Christine Feinle-Bisset, Asimina Kallas, Judith M. Wishart, Peter M. Clifton, Michael Horowitz and Natalie D. Luscombe-Marsh
dc.identifier.citationAmerican Journal of Clinical Nutrition, 2012; 96(3):474-482
dc.identifier.doi10.3945/ajcn.112.038133
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.orcidHutchison, A. [0000-0002-6393-3671]
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]
dc.identifier.orcidClifton, P. [0000-0002-6411-626X]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidLuscombe-Marsh, N. [0000-0001-9690-4722]
dc.identifier.urihttp://hdl.handle.net/2440/73612
dc.language.isoen
dc.publisherAmer Soc Clinical Nutrition
dc.rights© 2012 American Society for Nutrition
dc.source.urihttps://doi.org/10.3945/ajcn.112.038133
dc.subjectDuodenum
dc.subjectPyloric Antrum
dc.subjectHumans
dc.subjectGastrointestinal Hormones
dc.subjectInsulin
dc.subjectBlood Glucose
dc.subjectDietary Proteins
dc.subjectMilk Proteins
dc.subjectProtein Hydrolysates
dc.subjectCross-Over Studies
dc.subjectDouble-Blind Method
dc.subjectEnergy Intake
dc.subjectAppetite Regulation
dc.subjectGastrointestinal Motility
dc.subjectPostprandial Period
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectNew Zealand
dc.subjectMale
dc.subjectYoung Adult
dc.subjectWhey Proteins
dc.titleIntraduodenal protein modulates antropyloroduodenal motility, hormone release, glycemia, appetite, and energy intake in lean men
dc.typeJournal article
pubs.publication-statusPublished

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