Management of advanced gastric cancer

Simple item page
dc.contributor.authorPrice, T.
dc.contributor.authorShapiro, J.
dc.contributor.authorSegelov, E.
dc.contributor.authorKarapetis, C.
dc.contributor.authorPavlakis, N.
dc.contributor.authorVan Custem, E.
dc.contributor.authorShah, M.
dc.contributor.authorKang, Y.
dc.contributor.authorTebbutt, N.
dc.date.issued2012
dc.description.abstractThe management of advanced gastric cancer has only evolved a little over the last 15 years: platinum and fluoropyrimidine chemotherapy remains the backbone of therapy with ongoing debate as to the benefit of triplet therapy with either an anthracycline or taxane. Recently published trials of biological agents, in particular those targeting the Her2 receptor, have provided some signs of improvement. This article summarizes the relevant literature, discusses the role of these agents, as well as geographical variations in use, and provides recommendations regarding both ‘standard chemotherapy’ and the role of biological agents in advanced gastric cancer. Given the relative lack of progress for gastric cancer over the last 15 years, the focus for the next 5 years should be on an improved understanding of the molecular basis of gastric cancer, thus allowing rational integration of new molecular agents.
dc.description.statementofresponsibilityTimothy J. Price, Jeremy D. Shapiro, Eva Segelov, Christos S. Karapetis, Nick Pavlakis, Eric Van Cutsem, Manish A. Shah and Niall C. Tebbutt
dc.identifier.citationExpert Review of Gastroenterology and Hepatology, 2012; 6(2):199-209
dc.identifier.doi10.1586/egh.11.103
dc.identifier.issn1747-4124
dc.identifier.issn1747-4132
dc.identifier.orcidPrice, T. [0000-0002-3922-2693]
dc.identifier.urihttp://hdl.handle.net/2440/76420
dc.language.isoen
dc.publisherExpert Reviews Ltd.
dc.rights© 2012 Expert Reviews Ltd.
dc.source.urihttps://doi.org/10.1586/egh.11.103
dc.subjectHumans
dc.subjectAdenocarcinoma
dc.subjectStomach Neoplasms
dc.subjectAntineoplastic Agents
dc.subjectTreatment Outcome
dc.subjectEvidence-Based Medicine
dc.subjectSignal Transduction
dc.subjectPractice Guidelines as Topic
dc.subjectMolecular Targeted Therapy
dc.titleManagement of advanced gastric cancer
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications