Differential expression and distribution of syndecan-1 and -2 in the developing periodontium of the rat

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dc.contributor.authorWorapamorn, W.
dc.contributor.authorLi, H.
dc.contributor.authorYoung, W.
dc.contributor.authorBartold, P.
dc.date.issued2001
dc.description.abstractCell surface proteoglycans are known to interact with adhesion molecules, growth factors and a variety of other effector molecules implying their central role in various aspects of cell-cell and cell-matrix interactions. To investigate the expression and distribution of the cell surface proteoglycans syndecan-1 and -2, the developing periodontal tissues of 3-, 5-, and 8-wk-old male Lewis rats, were stained by specific monoclonal antibodies against syndecan-1, or -2 core protein, using immunohistochemical techniques. The results demonstrated that syndecan-1 and -2 were expressed and distributed differentially in several compartments of the developing periodontal tissues at different ages. Expression of syndecan-1 was noted in areas of intense cellular activity such as the developing apical root tip of the tooth and at the crestal bone where new bone formation was taking place. In contrast, syndecan-2 expression and distribution did not exhibit the same patterns as syndecan-1. Syndecan-2 showed significant differences of distribution in hard tissues undergoing maturation at different ages. These findings indicate that syndecan-1 and -2 may have distinctive functions during morphogenesis, organogenesis and differentiation of the periodontium.
dc.identifier.citationConnective Tissue Research, 2001; 42(1):39-48
dc.identifier.doi10.3109/03008200109014247
dc.identifier.issn0300-8207
dc.identifier.issn1607-8438
dc.identifier.orcidBartold, P. [0000-0002-5695-3877] [0000-0002-6225-3084]
dc.identifier.urihttp://hdl.handle.net/2440/39693
dc.language.isoen
dc.publisherGordon Breach Sci Publ Ltd
dc.source.urihttps://doi.org/10.3109/03008200109014247
dc.subjectPeriodontium
dc.subjectAnimals
dc.subjectRats, Inbred Lew
dc.subjectRats
dc.subjectProteoglycans
dc.subjectMembrane Glycoproteins
dc.subjectImmunoenzyme Techniques
dc.subjectTissue Distribution
dc.subjectMale
dc.subjectSyndecan-1
dc.subjectSyndecans
dc.subjectSyndecan-2
dc.titleDifferential expression and distribution of syndecan-1 and -2 in the developing periodontium of the rat
dc.typeJournal article
pubs.publication-statusPublished

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