PEGylated doxorubicin micelles loaded with curcumin exerting synergic effects on multidrug resistant tumor cells
Date
2017
Authors
Huang, S.
Liu, J.
Zhu, H.
Hussain, A.
Liu, Q.
Li, J.
Shen, Y.
Cheng, J.
Guo, S.
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Journal article
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Journal of Nanoscience and Nanotechnology, 2017; 17(5):2873-2880
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Abstract
A novel folate-polyethylene glycol-succinic acid-doxorubicin conjugate (FA-PEG-SA-DOX) micelle loaded with curcumin (CUR) is designed and prepared to target tumor cells via folate-folate receptor interactions and co-deliver chemotherapeutic agent DOX and chemosensitizer CUR for treatment of multidrug resistant human breast cancer MCF-7/ADR cells. The CUR/FA-PEG-SA-DOX micelles are characterized with the average size of 90.64±0.15 nm and the zeta potential of -15.3±0.8 mV. The CUR and DOX contents of the micelles are 12.07 and 15.69% (w/w), respectively. The cytotoxicity, cellular uptake and efflux of the micelles are investigated by using MCF-7/ADR cells. The results demonstrate that the CUR/FA-PEG-SA-DOX micelles have greater toxicity (IC50 =3.10 μg/ml) compared to the free DOX (IC50 = 31.99 μg/ml), moreover, the micelles present increased cellular uptake and reduced cellular efflux. The combination index of CUR/FA-PEG-SA-DOX micelles was 0.17, which indicate a strong synergistic antitumor efficacy against MCF-7/ADR cells. These results suggest that Curcumin-loaded FA-PEG-SA-DOX micelles may be a promising nanomedicine for co-delivery dual-drug treatment for cancer
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Copyright 2017 American Scientific Publishers