Effects of energy-restricted diets containing increased protein on weight loss, resting energy expenditure, and the thermic effect of feeding of type 2 diabetes

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dc.contributor.authorLuscombe-Marsh, N.
dc.contributor.authorClifton, P.
dc.contributor.authorNoakes, M.
dc.contributor.authorParker, B.
dc.contributor.authorWittert, G.
dc.date.issued2002
dc.descriptionCopyright © 2002 by the American Diabetes Association, Inc.
dc.description.abstractObjective - To determine the effect of a high-protein (HP) diet compared with a low-protein (LP) diet on weight loss, resting energy expenditure (REE), and the thermic effect of food (TEF) in subjects with type 2 diabetes during moderate energy restriction. Research design and methods - In this study, 26 obese subjects with type 2 diabetes consumed a HP (28% protein, 42% carbohydrate) or LP diet (16% protein, 55% carbohydrate) during 8 weeks of energy restriction (1,600 kcal/day) and 4 weeks of energy balance. Body weight and composition and REE were measured, and the TEF in response to a HP or LP meal was determined for 2 h, at weeks 0 and 12. Results - The mean weight loss was 4.6 ± 0.4 kg (P < 0.001), of which 4.5 ± 0.4 kg was fat (P < 0.001), with no effect of diet (P = 0.6). At both weeks 0 and 12, TEF was greater after the HP than after the LP meal (0.064 vs. 0.050 kcal · kcal-1 energy consumed · 2 h-1, respectively; overall diet effect, P = 0.003). REE and TEF were reduced similarly with each of the diets (time effects, P = 0.02 and P < 0.001, respectively). Conclusions - In patients with type 2 diabetes, a low-fat diet with an increased protein-to-carbohydrate ratio does not significantly increase weight loss or blunt the fall in REE.
dc.description.statementofresponsibilityN.D. Luscombe, P.M. Clifton, M. Noakes, B. Parker, and G. Wittert
dc.identifier.citationDiabetes Care, 2002; 25(4):652-657
dc.identifier.doi10.2337/diacare.25.4.652
dc.identifier.issn0149-5992
dc.identifier.issn1935-5548
dc.identifier.orcidLuscombe-Marsh, N. [0000-0001-9690-4722]
dc.identifier.orcidClifton, P. [0000-0002-6411-626X]
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]
dc.identifier.urihttp://hdl.handle.net/2440/9403
dc.language.isoen
dc.publisherAmer Diabetes Assoc
dc.source.urihttps://doi.org/10.2337/diacare.25.4.652
dc.subjectHumans
dc.subjectDiabetes Mellitus
dc.subjectDiabetes Mellitus, Type 2
dc.subjectObesity
dc.subjectBody Weight
dc.subjectWeight Loss
dc.subjectDietary Fats
dc.subjectDietary Proteins
dc.subjectBasal Metabolism
dc.subjectBody Composition
dc.subjectEnergy Metabolism
dc.subjectEnergy Intake
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectDiet, Diabetic
dc.titleEffects of energy-restricted diets containing increased protein on weight loss, resting energy expenditure, and the thermic effect of feeding of type 2 diabetes
dc.typeJournal article
pubs.publication-statusPublished

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