Immobilisation versus immediate mobilisation after intrauterine insemination: randomised controlled trial

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dc.contributor.authorCusters, I.
dc.contributor.authorFlierman, P.
dc.contributor.authorMaas, P.
dc.contributor.authorCox, T.
dc.contributor.authorVan Dessel, T.
dc.contributor.authorGerards, M.
dc.contributor.authorMochtar, M.
dc.contributor.authorJanssen, C.
dc.contributor.authorvan der Veen, F.
dc.contributor.authorMol, B.
dc.date.issued2009
dc.description.abstractObjective To evaluate the effectiveness of 15 minutes of immobilisation versus immediate mobilisation after intrauterine insemination. Design Randomised controlled trial. Setting One academic teaching hospital and six non-academic teaching hospitals. Participants Women having intrauterine insemination for unexplained, cervical factor, or male subfertility. Interventions 15 minutes of immobilisation or immediate mobilisation after insemination. Main outcome measure Ongoing pregnancy per couple. Results 391 couples were randomised; 199 couples were allocated to 15 minutes of immobilisation after intrauterine insemination, and 192 couples were allocated to immediate mobilisation (control). The ongoing pregnancy rate per couple was significantly higher in the immobilisation group than in the control group: 27% (n=54) versus 18% (34); relative risk 1.5, 95% confidence interval 1.1 to 2.2 (crude difference in ongoing pregnancy rates: 9.4%, 1.2% to 17%). Live birth rates were 27% (53) in the immobilisation group and 17% (32) in the control group: relative risk 1.6, 1.1 to 2.4 (crude difference for live birth rates: 10%, 1.8% to 18%). In the immobilisation group, the ongoing pregnancy rates in the first, second, and third treatment cycles were 10%, 10%, and 7%. The corresponding rates in the mobilisation group were 7%, 5%, and 5%. Conclusion In treatment with intrauterine insemination, 15 minutes' immobilisation after insemination is an effective modification. Immobilisation for 15 minutes should be offered to all women treated with intrauterine insemination. Trial registration Current Controlled Trials ISRCTN53294431.
dc.description.statementofresponsibilityInge M Custers, Paul A Flierman, Pettie Maas, Tessa Cox, Thierry J H M Van Dessel, Mariette H Gerards, Monique H Mochtar, Catharina A H Janssen, Fulco van der Veen and Ben Willem J Mol
dc.identifier.citationBMJ: British Medical Journal, 2009; 339(7729):1065-1067
dc.identifier.doi10.1136/bmj.b4080
dc.identifier.issn1756-1833
dc.identifier.issn1756-1833
dc.identifier.orcidMol, B. [0000-0001-6887-0262] [0000-0001-8337-550X]
dc.identifier.urihttp://hdl.handle.net/2440/86936
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.1136/bmj.b4080
dc.subjectHumans
dc.subjectInfertility, Male
dc.subjectInfertility, Female
dc.subjectInsemination, Artificial
dc.subjectEarly Ambulation
dc.subjectPregnancy Rate
dc.subjectImmobilization
dc.subjectPregnancy
dc.subjectSupine Position
dc.subjectTime Factors
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectLive Birth
dc.subjectYoung Adult
dc.subjectKaplan-Meier Estimate
dc.titleImmobilisation versus immediate mobilisation after intrauterine insemination: randomised controlled trial
dc.typeJournal article
pubs.publication-statusPublished

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