Recent developments in relaxin mimetics as therapeutics for cardiovascular diseases

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dc.contributor.authorLeo, C.H.
dc.contributor.authorJelinic, M.
dc.contributor.authorNg, H.H.
dc.contributor.authorParry, L.J.
dc.contributor.authorTare, M.
dc.date.issued2019
dc.description.abstractCardiovascular disease is the most common cause of mortality worldwide, accounting for almost 50% of all deaths globally. Vascular endothelial dysfunction and fibrosis are critical in the pathophysiology of cardiovascular disease. Relaxin, an insulinlike peptide, is known to have beneficial actions in the cardiovascular system through its vasoprotective and antifibrotic effects. However, relaxin has several limitations of peptide-based drugs such as poor oral bioavailability, laborious, and expensive to synthesize. This review will focus on recent developments in relaxin mimetics, their pharmacology, associated signalling mechanisms, and their therapeutic potential for the management and treatment of cardiovascular disease.
dc.description.statementofresponsibilityChen Huei Leo, Maria Jelinic, Hooi Hooi Ng, Laura J Parry, and Marianne Tare
dc.identifier.citationCurrent Opinion in Pharmacology, 2019; 45:42-48
dc.identifier.doi10.1016/j.coph.2019.04.001
dc.identifier.issn1471-4892
dc.identifier.issn1471-4973
dc.identifier.orcidParry, L.J. [0000-0002-6883-3418]
dc.identifier.urihttps://hdl.handle.net/2440/134382
dc.language.isoen
dc.publisherElsevier
dc.relation.grantNHMRC
dc.relation.grantARC
dc.rights© 2019 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.coph.2019.04.001
dc.subjectAnimals
dc.subjectHumans
dc.subjectCardiovascular Diseases
dc.subjectRelaxin
dc.subjectPeptide Fragments
dc.subjectBiomimetics
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshCardiovascular Diseases
dc.subject.meshRelaxin
dc.subject.meshPeptide Fragments
dc.subject.meshBiomimetics
dc.titleRecent developments in relaxin mimetics as therapeutics for cardiovascular diseases
dc.typeJournal article
pubs.publication-statusPublished

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