A single-nucleotide polymorphism in the gene encoding osteoprotegerin is associated with diastolic blood pressure in older men

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dc.contributor.authorGolledge, J.
dc.contributor.authorBiros, E.
dc.contributor.authorClancy, P.
dc.contributor.authorCooper, M.
dc.contributor.authorPalmer, L.
dc.contributor.authorNorman, P.
dc.date.issued2009
dc.description.abstract<h4>Background</h4>Osteoprotegerin (OPG) has been associated with cardiovascular events but currently the mechanisms underlying this association are unknown. OPG is thought to play a role in controlling artery calcification and small studies have suggested that it may influence artery structure. We examined the association between single nucleotide polymorphisms (SNPs) in the gene encoding OPG (tumor necrosis factor receptor superfamily, member 11b, TNFRSF11B), with blood pressure in a large cohort of elderly men.<h4>Methods</h4>21 tagging SNPs in the region encoded by TNFRSF11B were examined in 1,071 men recruited in a population-based study of elderly men. Genotyping was carried out using the Illumina Golden Gate assay. SNPs were investigated for their association with resting systolic and diastolic blood pressure after adjusting for other variables using linear regression. The association of SNPs in the region encoded by TNFRSF11B with plasma OPG was assessed in a random subset of 467 men.<h4>Results</h4>One SNP, rs11573901, was significantly associated with diastolic blood pressure, after adjusting for other risk factors and multiple testing (coefficient -4.36, P = 0.001). Men with the TC genotype had lower diastolic blood pressure than those with the common cc variation. this snp was not associated with plasma opg in the 467 men in which this was examined.<h4>Conclusions</h4>This study suggests that a SNP within the region encoded by TNFRSF11B, which is believed to code for OPG, is associated with blood pressure. The mechanism underlying this observed association is currently unclear.
dc.description.statementofresponsibilityJonathan Golledge, Erik Biros, Paula Clancy, Matthew Cooper, Lyle J. Palmer and Paul E. Norman
dc.identifier.citationAmerican Journal of Hypertension, 2009; 22(11):1167-1170
dc.identifier.doi10.1038/ajh.2009.177
dc.identifier.issn0895-7061
dc.identifier.issn1941-7225
dc.identifier.orcidPalmer, L. [0000-0002-1628-3055]
dc.identifier.urihttp://hdl.handle.net/2440/85032
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/540405
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/431503
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/458505
dc.rights© 2009 American Journal of Hypertension, Ltd.
dc.source.urihttps://doi.org/10.1038/ajh.2009.177
dc.subjectHumans
dc.subjectHypertension
dc.subjectCreatine
dc.subjectCholesterol
dc.subjectLipoproteins, HDL
dc.subjectLipoproteins, LDL
dc.subjectDNA Fingerprinting
dc.subjectBlood Pressure
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMale
dc.subjectOsteoprotegerin
dc.titleA single-nucleotide polymorphism in the gene encoding osteoprotegerin is associated with diastolic blood pressure in older men
dc.typeJournal article
pubs.publication-statusPublished

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