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Cardiovascular changes during morphine administration and spontaneous withdrawal in the rat.

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dc.contributor.authorChan, R.
dc.contributor.authorIrvine, R.
dc.contributor.authorWhite, J.
dc.date.issued1999
dc.description.abstractMorphine maintenance doses of 10 mg kg(-1) day(-1), 20 mg kg(-1) day(-1) and 30 mg kg(-1) day(-1) were administered to three groups of rats via miniosmotic pumps for 7 days to induce physical dependence. They were then allowed to undergo spontaneous withdrawal. Radiotelemetric blood pressure measurements showed that morphine increased systolic and diastolic blood pressure on the first day of morphine treatment and produced a dose dependent decrease in heart rate, systolic and diastolic blood pressure thereafter. After the peak depressive effect, development of tolerance to morphine was observed in systolic and diastolic blood pressure, but not in the heart rate. During spontaneous withdrawal, both systolic and diastolic blood pressure increased beyond pre-morphine levels for all doses and there was a rebound increase in heart rate at the 30 mg kg(-1) day(-1) dose. These results suggest that the improved sensitivity of telemetric measures combined with the use of minipumps for morphine treatment provide an animal model of spontaneous opioid withdrawal.
dc.identifier.citationEuropean Journal of Pharmacology, 1999; 368(1):25-33
dc.identifier.doi10.1016/S0014-2999(98)00984-4
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.urihttp://hdl.handle.net/2440/14433
dc.language.isoen
dc.publisherELSEVIER
dc.source.urihttps://doi.org/10.1016/s0014-2999(98)00984-4
dc.subjectAnimals
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectMorphine Dependence
dc.subjectSubstance Withdrawal Syndrome
dc.subjectMorphine
dc.subjectAnalgesics, Opioid
dc.subjectInfusion Pumps
dc.subjectMotor Activity
dc.subjectConsciousness
dc.subjectBlood Pressure
dc.subjectHeart Rate
dc.subjectSystole
dc.subjectMovement
dc.subjectDose-Response Relationship, Drug
dc.subjectTime Factors
dc.subjectMale
dc.subjectCardiovascular Physiological Phenomena
dc.titleCardiovascular changes during morphine administration and spontaneous withdrawal in the rat.
dc.typeJournal article
pubs.publication-statusPublished

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