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Erectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events: findings from a linked-data study

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dc.contributor.authorChew, K.K.
dc.contributor.authorFinn, J.
dc.contributor.authorStuckey, B.
dc.contributor.authorGibson, N.
dc.contributor.authorSanfilippo, F.
dc.contributor.authorBremner, A.
dc.contributor.authorThompson, P.
dc.contributor.authorHobbs, M.
dc.contributor.authorJamrozik, K.
dc.date.issued2009
dc.description.abstractIntroduction: In spite of the mounting interest in the nexus between erectile dysfunction (ED) and cardiovascular (CV) diseases, there is little published information on the role of ED as a predictor for subsequent CV events. Aim: This study aimed to investigate the role of ED as a predictor for atherosclerotic CV events subsequent to the manifestation of ED. Method: The investigation involved the retrospective study of data on a cohort of men with ED linked to hospital morbidity data and death registrations. By using the linked data, the incidence rates of atherosclerotic CV events subsequent to the manifestation of ED were estimated in men with ED and no atherosclerotic CV disease reported prior to the manifestation of ED. The risk of subsequent atherosclerotic CV events in men with ED was assessed by comparing these incidence rates with those in the general male population. Main Outcome Measure: Standardized incidence rate ratio (SIRR), comparing the incidence of atherosclerotic CV events subsequent to the manifestation of ED in a cohort of 1,660 men with ED to the incidence in the general male population. Results: On the basis of hospital admissions and death registrations, men with ED had a statistically significantly higher incidence of atherosclerotic CV events (SIRR 2.2; 95% confidence interval 1.9, 2.4). There were significantly increased incidence rate ratios in all age groups younger than 70 years, with a statistically highly significant downward trend with increase of age (Pā€ƒ<ā€ƒ0.0001) across these age groups. Younger age at first manifestation of ED, cigarette smoking, presence of comorbidities and socioeconomic disadvantage were all associated with higher hazard ratios for subsequent atherosclerotic CV events. Conclusions: The findings show that ED is not only significantly associated with but is also strongly predictive of subsequent atherosclerotic CV events. This is even more striking when ED presents at a younger age.
dc.identifier.citationJournal of Sexual Medicine, 2009; 7(1, part 1):192-202
dc.identifier.doi10.1111/j.1743-6109.2009.01576.x
dc.identifier.issn1743-6095
dc.identifier.issn1743-6109
dc.identifier.urihttps://hdl.handle.net/1959.8/132531
dc.language.isoen
dc.publisherWiley-Blackwell Publishing Ltd.
dc.rightsCopyright 2009 International Society for Sexual Medicine
dc.source.urihttps://doi.org/10.1111/j.1743-6109.2009.01576.x
dc.subjectatherosclerotic cardiovascular events
dc.subjectendothelial dysfunction
dc.subjecterectile dysfunction
dc.subjectlinked-data study
dc.subjectHumans
dc.subjectIntracranial Arteriosclerosis
dc.subjectImpotence, Vasculogenic
dc.subjectArterial Occlusive Diseases
dc.subjectPatient Admission
dc.subjectData Collection
dc.subjectHealth Surveys
dc.subjectIncidence
dc.subjectRisk Factors
dc.subjectRetrospective Studies
dc.subjectCohort Studies
dc.subjectCross-Sectional Studies
dc.subjectComorbidity
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectWestern Australia
dc.subjectMale
dc.subjectCoronary Artery Disease
dc.subjectYoung Adult
dc.titleErectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events: findings from a linked-data study
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915910799601831

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