Substance P in pain
Date
2024
Authors
Vink, R.
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Vink, R.
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Book chapter
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Source details - Title: Substance P: from Pain to Cancer, 2024 / Vink, R. (ed./s), Ch.15, pp.357-372
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Abstract
Following noxious stimulation, the neuropeptide substance P is released both peripherally and in the central nervous system (CNS), binding to its NK1 receptor and contributing to nociception. However, despite the initial excitement surrounding the blockade of spinal NK1 receptors as a potential clinical analgesic, substance P is now widely considered to be more of a neuromodulator of the pain response in the CNS rather than the primary nociceptive neurotransmitter. Nonetheless, it is a critical player in neuronal sensitization to pain, as well as playing a major role in cortical processing of the pain response in the brain, including the emotional aspects of pain. The current review will summarize the historical data supporting a role for substance P in nociception, the preclinical studies examining NK1 antagonists as antinociceptive agents, attempts at clinical translation, and recent developments supporting further research into NK1 antagonists as clinical analgesics.
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