Leptin expression in offspring is programmed by nutrition in pregnancy

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dc.contributor.authorEkert, J.
dc.contributor.authorGatford, K.
dc.contributor.authorLuxford, B.
dc.contributor.authorCampbell, R.
dc.contributor.authorOwens, P.
dc.date.issued2000
dc.description.abstractBirth weight is a determinant of blood leptin concentrations in adults. Since nutrition during pregnancy can affect birth weight, the hypothesis that feed intake during pregnancy alters leptin expression in progeny was examined. Leptin mRNA was measured in subcutaneous adipose tissue and leptin protein was measuredin blood plasma from 59 day old female pigs whose mothers were fed at the same restricted rate except that half were permitted to consume 35% more feed during the second quarter of pregnancy. Leptin mRNA abundance in adipose tissue (P=0.015) and plasma leptin concentration (P=0.01) were higher in progeny from mothers provided with more feed. Body weight at birth was negatively correlated with the abundance of leptin mRNA in subcutaneous fat at 59 days of age (P=0.01). This study shows for the first time that maternal nutrition during pregnancy programs postnatal leptin expression in offspring.
dc.description.statementofresponsibilityJE Eckert, KL Gatford, BG Luxford, RG Campbell, and PC Owens
dc.identifier.citationJournal of Endocrinology, 2000; 165(3):R1-R6
dc.identifier.doi10.1677/joe.0.165R001
dc.identifier.issn0022-0795
dc.identifier.issn1479-6805
dc.identifier.orcidGatford, K. [0000-0002-2823-3004]
dc.identifier.urihttp://hdl.handle.net/2440/11881
dc.language.isoen
dc.publisherSoc Endocrinology
dc.rights© 2000 by Society for Endocrinology
dc.source.urihttp://joe.endocrinology-journals.org/cgi/content/abstract/165/3/R1
dc.subjectAdipose Tissue
dc.subjectAnimals
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectBirth Weight
dc.subjectLeptin
dc.subjectRNA, Messenger
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectPregnancy
dc.subjectPregnancy, Animal
dc.subjectFemale
dc.subjectAnimal Nutritional Physiological Phenomena
dc.titleLeptin expression in offspring is programmed by nutrition in pregnancy
dc.typeJournal article
pubs.publication-statusPublished

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