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Systemic Inflammation Predicts Alzheimer Pathology in Community Samples without Dementia

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hdl_136091.pdf (758.23 KB)
  (Published version)

Date

2022

Authors

Cherbuin, N.
Walsh, E.I.
Leach, L.
Brüstle, A.
Burns, R.
Anstey, K.J.
Sachdev, P.S.
Baune, B.T.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

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Journal article

Citation

Biomedicines, 2022; 10(6):1240-1-1240-14

Statement of Responsibility

Nicolas Cherbuin, Erin I. Walsh, Liana Leach, Anne Brüstle, Richard Burns, Kaarin J. Anstey, Perminder S. Sachdev, and Bernhard T. Baune

Conference Name

DOI

10.3390/biomedicines10061240

Abstract

Neuroinflammation and oxidative stress (OS) are implicated in the pathophysiology of Alzheimer’s disease (AD). However, it is unclear at what stage of the disease process inflammation first becomes manifest. The aim of this study was to investigate the associations between specific plasma markers of inflammation and OS, tau, and Amyloid-beta 38, 40, and 42 levels in cognitively unimpaired middle-age and older individuals. Associations between inflammatory states identified through principal component analysis and AD biomarkers were investigated in middle-age (52–56 years, n = 335, 52% female) and older-age (72–76 years, n = 351, 46% female) participants without dementia. In middle-age, a component reflecting variation in OS was most strongly associated with tau and to a lesser extent amyloid-beta levels. In older-age, a similar component to that observed in middle-age was only associated with tau, while another component reflecting heightened inflammation independent of OS, was associated with all AD biomarkers. In middle and older-age, inflammation and OS states are associated with plasma AD biomarkers.

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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

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Grant ID

http://purl.org/au-research/grants/nhmrc/973302
 http://purl.org/au-research/grants/nhmrc/179805
 http://purl.org/au-research/grants/nhmrc/157125
 http://purl.org/au-research/grants/nhmrc/1063907
 http://purl.org/au-research/grants/nhmrc/568969
 http://purl.org/au-research/grants/arc/120100227
 http://purl.org/au-research/grants/arc/FL190100011

Published Version

https://doi.org/10.3390/biomedicines10061240

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Persistent link to this record

https://hdl.handle.net/2440/136091