Current studentsExisting staffContact us
 

In-hospital mortality and morbidity in cancer patients with COVID-19: a nationwide analysis from the United States

Simple item page
dc.contributor.authorAbuhelwa, Z.
dc.contributor.authorAlsughayer, A.
dc.contributor.authorAbuhelwa, A.Y.
dc.contributor.authorBeran, A.
dc.contributor.authorSayeh, W.
dc.contributor.authorKhokher, W.
dc.contributor.authorSajdeya, O.
dc.contributor.authorKhuder, S.
dc.contributor.authorAssaly, R.
dc.contributor.editorWong, D.
dc.date.issued2022
dc.descriptionData source: Supplementary materials, https://doi.org/10.3390/cancers15010222
dc.description.abstractSimple Summary: Patients with cancer are considered a vulnerable population and might have an increased risk for severe outcomes of coronavirus disease 2019 (COVID-19). We used the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (NIS) 2020 database, the largest inpatient database in the United States, to assess COVID-19 outcomes in cancer patients. We have demonstrated that cancer patients hospitalized for COVID-19 have increased odds of all-cause in-hospital mortality and acute respiratory failure compared with non-cancer patients. Lung cancer patients have been demonstrated to have the worst mortality outcome. Background: Coronavirus disease 2019 (COVID-19) caused significant mortality and mortality worldwide. There is limited information describing the outcomes of COVID-19 in cancer patients. Methods: We utilized the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (NIS) 2020 database to collect information on cancer patients hospitalized for COVID-19 in the United States. Using the International Classification of Diseases, 10th revision, Clinical Modification (ICD-10-CM) coding system, adult (≥18 years) patients with COVID-19 were identified. Adjusted analyses were performed to assess for mortality, morbidity, and resource utilization among cancer patients. Results: A total of 1,050,045 patients were included. Of them, 27,760 had underlying cancer. Cancer patients were older and had more comorbidities. The all-cause in-hospital mortality rate in cancer patients was 17.58% vs. 11% in non-cancer. After adjusted logistic regression, cancer patients had a 21% increase in the odds of all-cause in-hospital mortality compared with those without cancer (adjusted odds ratio (aOR) 1.21, 95%CI 1.12–1.31, p-value < 0.001). Additionally, an increased odds in acute respiratory failure rate was found (aOR 1.14, 95%CI 1.06–1.22, p-value < 0.001). However, no significant differences were found in the odds of septic shock, acute respiratory distress syndrome, and mechanical ventilation between the two groups. Additionally, no significant differences in the mean length of hospital stay and the total hospitalization charges between cancer and non-cancer patients. Conclusion: Cancer patients hospitalized for COVID-19 had increased odds of all-cause in hospital mortality and acute respiratory failure compared with non-cancer patients.
dc.identifier.citationCancers, 2022; 15(1):.1-.11
dc.identifier.doi10.3390/cancers15010222
dc.identifier.issn2072-6694
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/11541.2/32244
dc.language.isoen
dc.publisherMDPI AG
dc.rightsCopyright 2022 The authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. (https://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.3390/cancers15010222
dc.subjectcancer
dc.subjectmortality
dc.subjectmorbidity
dc.subjectCOVID-19
dc.titleIn-hospital mortality and morbidity in cancer patients with COVID-19: a nationwide analysis from the United States
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12257179700001831 13257179690001831 In-hospital mortality and morbidity in cancer patients with COVID-19: a nationwide analysis from the United States
ror.mmsid9916708821301831

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
In-hospital mortality and morbidity in cancer patients with COVID-19 - a nationwide analysis from the United States.pdf
Size:
919.39 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections