Strategies and methods for the attachment of amino acids and peptides to chiral [n]polynorbornane templates
Date
2003
Authors
Pfeffer, F.
Russell, R.
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Journal article
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Organic and Biomolecular Chemistry, 2003; 1(11):1845-1851
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Abstract
A versatile synthesis of amino acid and peptide functionalised [n]polynorbornane scaffolds is described. The frameworks are constructed using the stereoselective and regioselective cycloaddition of suitably functionalisedchiral cyclobutene epoxides with similar norbornenes. The strategies employed allow a range of topologies to be accessed and a number of regioselectively addressable linkage points to be accommodated.
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© The Royal Society of Chemistry 2003