Glucagon-like peptides 1 and 2 in health and disease: A review

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dc.contributor.authorMarathe, C.
dc.contributor.authorRayner, C.
dc.contributor.authorJones, K.
dc.contributor.authorHorowitz, M.
dc.date.issued2013
dc.description.abstractThe gut derived peptides, glucagon-like peptides 1 and 2 (GLP-1 and GLP-2), are secreted following nutrient ingestion. GLP-1 and another gut peptide, glucose-dependent insulinotropic polypeptide (GIP) are collectively referred to as 'incretin' hormones, and play an important role in glucose homeostasis. Incretin secretion shares a complex interdependent relationship with both postprandial glycemia and the rate of gastric emptying. GLP-1 based therapies are now well established in the management of type 2 diabetes, while recent literature has suggested potential applications to treat obesity and protect against cardiovascular and neurological disease. The mechanism of action of GLP-2 is not well understood, but it shows promise as an intestinotropic agent.
dc.description.statementofresponsibilityChinmay S. Marathe, Christopher K. Rayner, Karen L. Jones, Michael Horowitz
dc.identifier.citationPeptides, 2013; 44:75-86
dc.identifier.doi10.1016/j.peptides.2013.01.014
dc.identifier.issn0196-9781
dc.identifier.issn1873-5169
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.urihttp://hdl.handle.net/2440/80360
dc.language.isoen
dc.publisherElsevier Science Inc
dc.rights© 2013 Elsevier Inc. All rights reserved.
dc.source.urihttp://www.sciencedirect.com/science/article/pii/S0196978113000338
dc.subjectPancreas
dc.subjectAnimals
dc.subjectHumans
dc.subjectDiabetes Mellitus, Type 2
dc.subjectBlood Glucose
dc.subjectReceptors, Glucagon
dc.subjectGastric Emptying
dc.subjectPostprandial Period
dc.subjectGlucagon-Like Peptide 1
dc.subjectGlucagon-Like Peptide 2
dc.subjectClinical Trials as Topic
dc.subjectIncretins
dc.titleGlucagon-like peptides 1 and 2 in health and disease: A review
dc.typeJournal article
pubs.publication-statusPublished

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