Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI

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dc.contributor.authorTsai, V.
dc.contributor.authorMacia, L.
dc.contributor.authorFeinle-Bisset, C.
dc.contributor.authorManandhar, R.
dc.contributor.authorAstrup, A.
dc.contributor.authorRaben, A.
dc.contributor.authorLorenzen, J.
dc.contributor.authorSchmidt, P.
dc.contributor.authorWiklund, F.
dc.contributor.authorPedersen, N.
dc.contributor.authorCampbell, L.
dc.contributor.authorKriketos, A.
dc.contributor.authorXu, A.
dc.contributor.authorZhou, P.
dc.contributor.authorJia, W.
dc.contributor.authorCurmi, P.
dc.contributor.authorAngstmann, C.
dc.contributor.authorLee-Ng, K.
dc.contributor.authorZhang, H.
dc.contributor.authorMarquis, C.
dc.contributor.authoret al.
dc.contributor.editorYoung, M.
dc.date.issued2015
dc.description.abstractThe TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC-1/GDF15 on feeding centres in the hypothalamus and brainstem. More recent studies in germline gene deleted mice also suggest that this cytokine may play a role in physiological regulation of energy homeostasis. To further characterize the role of MIC-1/GDF15 in physiological regulation of energy homeostasis in man, we have examined diurnal and food associated variation in serum levels and whether variation in circulating levels relate to BMI in human monozygotic twin pairs. We found that the within twin pair differences in serum MIC-1/GDF15 levels were significantly correlated with within twin pair differences in BMI, suggesting a role for MIC-1/GDF15 in the regulation of energy balance in man. MIC-1/GDF15 serum levels altered slightly in response to a meal, but comparison with variation its serum levels over a 24 hour period suggested that these changes are likely to be due to bimodal diurnal variation which can alter serum MIC-1/GDF15 levels by about plus or minus 10% from the mesor. The lack of a rapid and substantial postprandial increase in MIC-1/GDF15 serum levels suggests that MIC1/GDF15 is unlikely to act as a satiety factor. Taken together, our findings suggest that MIC-1/GDF15 may be a physiological regulator of energy homeostasis in man, most probably due to actions on long-term regulation of energy homeostasis.
dc.description.statementofresponsibilityVicky Wang-Wei Tsai ... Christine Feinle-Bisset ... et al.
dc.identifier.citationPLoS ONE, 2015; 10(7):e0133362-1-e0133362-15
dc.identifier.doi10.1371/journal.pone.0133362
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]
dc.identifier.urihttp://hdl.handle.net/2440/94718
dc.language.isoen
dc.publisherPublic Library of Science
dc.relation.grantNHMRC
dc.rights© 2015 Tsai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.urihttps://doi.org/10.1371/journal.pone.0133362
dc.subjectHumans
dc.subjectCholecystokinin
dc.subjectBody Mass Index
dc.subjectSatiation
dc.subjectEnergy Metabolism
dc.subjectCircadian Rhythm
dc.subjectTwins
dc.subjectPostprandial Period
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectGlucagon-Like Peptide 1
dc.subjectGrowth Differentiation Factor 15
dc.subjectYoung Adult
dc.titleSerum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI
dc.typeJournal article
pubs.publication-statusPublished

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