The effects of long-term CPAP on weight change in patients with comorbid OSA and cardiovascular disease: data from the SAVE trial

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dc.contributor.authorOu, Q.
dc.contributor.authorChen, B.
dc.contributor.authorLoffler, K.A.
dc.contributor.authorLuo, Y.
dc.contributor.authorZhang, X.
dc.contributor.authorChen, R.
dc.contributor.authorWang, Q.
dc.contributor.authorDrager, L.F.
dc.contributor.authorLorenzi-Filho, G.
dc.contributor.authorHlavac, M.
dc.contributor.authorMcArdle, N.
dc.contributor.authorMukherjee, S.
dc.contributor.authorMediano, O.
dc.contributor.authorBarbe, F.
dc.contributor.authorAnderson, C.S.
dc.contributor.authorMcEvoy, R.D.
dc.contributor.authorWoodman, R.J.
dc.date.issued2019
dc.description.abstractBackground: Although recent evidence suggests that OSA treatment may cause weight gain, the long-term effects of CPAP on weight are not well established. Methods: This study was a post hoc analysis of the Sleep Apnea Cardiovascular Endpoints (SAVE) study, a multicenter, randomized trial of CPAP plus standard care vs standard care alone in adults with a history of cardiac or cerebrovascular events and moderate to severe OSA. Participants with weight, BMI, and neck and waist circumferences measured at baseline and during follow-up were included. Linear mixed models were used to examine sex-specific temporal differences, and a sensitivity analysis compared high CPAP adherers (≥ 4 h per night) with propensity-matched control participants. Results: A total of 2,483 adults (1,248 in the CPAP group and 1,235 in the control group) were included (mean 6.1 ± 1.5 measures of weight available). After a mean follow-up of 3.78 years, there was no difference in weight change between the CPAP and control groups, for male subjects (mean [95% CI] between-group difference, 0.07 kg [-0.40 to 0.54]; P = .773) or female subjects (mean [95% CI] between-group difference, -0.14 kg [-0.37 to 0.09]; P = .233). Similarly, there were no significant differences in BMI or other anthropometric measures. Although male participants who used CPAP ≥ 4 h per night gained slightly more weight than matched male control subjects without CPAP (mean difference, 0.38 kg [95% CI, 0.04 to 0.73]; P = .031), there were no between-group differences in other anthropometric variables, nor were there any differences between female high CPAP adherers and matched control subjects. Conclusions: Long-term CPAP use in patients with comorbid OSA and cardiovascular disease does not result in clinically significant weight change.
dc.description.statementofresponsibilityQiong Ou, Baixin Chen, Kelly A. Loffler, Yuanming Luo, Xilong Zhang, Rui Chen, Qian Wang, Luciano F. Drager, Geraldo Lorenzi-Filho, Michael Hlavac, Nigel McArdle, Sutapa Mukherjee, Olga Mediano, Ferran Barbe, Craig S. Anderson, R. Doug McEvoy, Richard J. Woodman (on behalf of the SAVE investigators)
dc.identifier.citationChest, 2019; 155(4):720-729
dc.identifier.doi10.1016/j.chest.2018.08.1082
dc.identifier.issn0012-3692
dc.identifier.issn1931-3543
dc.identifier.orcidMcEvoy, R.D. [0000-0002-5759-0094]
dc.identifier.urihttp://hdl.handle.net/2440/119475
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1006501
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1060078
dc.rights© 2018 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.chest.2018.08.1082
dc.subjectCPAP; long-term; OSA; weight
dc.titleThe effects of long-term CPAP on weight change in patients with comorbid OSA and cardiovascular disease: data from the SAVE trial
dc.typeJournal article
pubs.publication-statusPublished

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