Treatment and prevention of enterohemorrhagic Escherichia coli infection and hemolytic uremic syndrome

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dc.contributor.authorGoldwater, P.
dc.date.issued2007
dc.description.abstractOver a quarter century after the discovery of verocytotoxin and the first report by Karmali and colleagues of cases of postdiarrheal hemolytic uremic syndrome (HUS) caused by verotoxigenic Escherichia coli (VTEC), otherwise known as Shiga-toxigenic E. coli (STEC), successful treatment of these infections has remained elusive. This is because the pathological insult producing the clinical picture of HUS occurs early in the disease process and curtails quickly, making treatment intervention a largely vain hope. Nevertheless, understanding of the pathogenesis of HUS has expanded and, as a result, we can expect a future breakthrough in the treatment of this life-threatening condition. This review examines the pathogenesis of HUS and explores targets for treatment, including the reasons why certain therapies have failed and why future therapies could be successful. This review also examines the status of vaccine development in prevention of VTEC/STEC disease.
dc.description.statementofresponsibilityGoldwater P.N.
dc.description.urihttp://www.ncbi.nlm.nih.gov/pubmed/17678428?ordinalpos=21&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
dc.identifier.citationExpert Review of Anti-Infective Therapy, 2007; 5(4):653-663
dc.identifier.doi10.1586/14787210.5.4.653
dc.identifier.issn1478-7210
dc.identifier.issn1744-8336
dc.identifier.orcidGoldwater, P. [0000-0003-4822-8488]
dc.identifier.urihttp://hdl.handle.net/2440/46245
dc.language.isoen
dc.publisherFuture Drugs Ltd.
dc.source.urihttps://doi.org/10.1586/14787210.5.4.653
dc.subjectAnimals
dc.subjectHumans
dc.subjectEscherichia coli O157
dc.subjectEscherichia coli Infections
dc.subjectHemolytic-Uremic Syndrome
dc.subjectVirulence Factors
dc.subjectEscherichia coli Vaccines
dc.subjectAntibodies, Monoclonal
dc.subjectAnti-Bacterial Agents
dc.subjectSerotyping
dc.subjectRisk Factors
dc.subjectProbiotics
dc.subjectGenetic Therapy
dc.titleTreatment and prevention of enterohemorrhagic Escherichia coli infection and hemolytic uremic syndrome
dc.typeJournal article
pubs.publication-statusPublished

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