Comparative genetics and innate immune functions of collagenous lectins in animals

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dc.contributor.authorLillie, Brandon L.en
dc.contributor.authorBrooks, Andrew S.en
dc.contributor.authorKeirstead, Natalie Danetteen
dc.contributor.authorHayes, M. Anthonyen
dc.contributor.schoolSchool of Veterinary Scienceen
dc.date.issued2005en
dc.description.abstractCollagenous lectins such as mannan-binding lectins (MBLs), ficolins (FCNs), surfactant proteins A and D (SP-A, SP-D), conglutinin (CG), and related ruminant lectins are multimeric proteins with carbohydrate-binding domains aligned in a manner that facilitates binding to microbial surface polysaccharides. MBLs and FCNs are structurally related to C1q, but activate the lectin complement pathway via interaction with MBL-associated serine proteases (MASPs). MBLs, FCNs, and other collagenous lectins also bind to some host macromolecules and contribute to their removal. While there is evidence that some lectins and the lectin complement pathway are conserved in vertebrates, many differences in collagenous lectins have been observed among humans, rodents, and other vertebrates. For example, humans have only one MBL but three FCNs, whereas most other species express two FCNs and two MBLs. Bovidae express CG and other SP-D-related collectins that are not found in monogastric species. Some dysfunctions of human MBL are due to single nucleotide polymorphisms (SNPs) that affect its expression or structure and thereby increase susceptibility to some infections. Collagenous lectins have well-established roles in innate immunity to various microorganisms, so it is possible that some lectin genotypes or induced phenotypes influence resistance to some infectious or inflammatory diseases in animals.en
dc.description.statementofresponsibilityBrandon N. Lillie, Andrew S. Brooks, Natalie D. Keirstead, M. Anthony Hayesen
dc.identifier.citationVeterinary Immunology and Immunopathology, 2005; 108(1-2):97-110en
dc.identifier.doi10.1016/j.vetimm.2005.07.001en
dc.identifier.issn0165-2427en
dc.identifier.urihttp://hdl.handle.net/2440/64607
dc.language.isoenen
dc.publisherElsevier Science BVen
dc.rights© 2005 Elsevier B.V. All rights reserved.en
dc.subjectLectins; Collectins; Ficolins; Innate immunity; Polymorphisms; Complementen
dc.titleComparative genetics and innate immune functions of collagenous lectins in animalsen
dc.typeJournal articleen

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