Comparative effects of prolonged and intermittent stimulation of the glucagon- like peptide 1 receptor on gastric emptying and glycemia

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dc.contributor.authorUmapathysivam, M.
dc.contributor.authorLee, M.
dc.contributor.authorJones, K.
dc.contributor.authorAnnink, C.
dc.contributor.authorCousins, C.
dc.contributor.authorTrahair, L.
dc.contributor.authorRayner, C.
dc.contributor.authorChapman, M.
dc.contributor.authorNauck, M.
dc.contributor.authorHorowitz, M.
dc.contributor.authorDeane, A.
dc.date.issued2014
dc.descriptionData source: Supplementary data, https://doi.org/10.2337/db13-0893
dc.description.abstractAcute administration of glucagon-like peptide 1 (GLP-1) and its agonists slows gastric emptying, which represents the major mechanism underlying their attenuation of postprandial glycemic excursions. However, this effect may diminish during prolonged use. We compared the effects of prolonged and intermittent stimulation of the GLP-1 receptor on gastric emptying and glycemia. Ten healthy men received intravenous saline (placebo) or GLP-1 (0.8 pmol/kg $ min), as a continuous 24-h infusion (“prolonged”), two 4.5-h infusions separated by 20 h (“intermittent”), and a 4.5-h infusion (“acute”) in a randomized, double-blind, crossover fashion. Gastric emptying of a radiolabeled mashed potato meal was measured using scintigraphy. Acute GLP-1 markedly slowed gastric emptying. The magnitude of the slowing was attenuated with prolonged but maintained with intermittent infusions. GLP-1 potently diminished postprandial glycemia during acute and intermittent regimens. These observations suggest that short-acting GLP-1 agonists may be superior to long-acting agonists when aiming specifically to reduce postprandial glycemic excursions in the treatment of type 2 diabetes.
dc.description.statementofresponsibilityMahesh M. Umapathysivam, Michael Y. Lee, Karen L. Jones,Christopher E. Annink, Caroline E. Cousins, Laurence G. Trahair, Chris K. Rayner, Marianne J. Chapman, Michael A. Nauck, Michael Horowitz, and Adam M. Deane
dc.identifier.citationDiabetes, 2014; 63(2):785-790
dc.identifier.doi10.2337/db13-0893
dc.identifier.issn0012-1797
dc.identifier.issn1939-327X
dc.identifier.orcidUmapathysivam, M. [0000-0001-8959-5239]
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]
dc.identifier.orcidChapman, M. [0000-0003-0710-3283]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidDeane, A. [0000-0002-7620-5577]
dc.identifier.urihttp://hdl.handle.net/2440/82080
dc.language.isoen
dc.publisherAmerican Diabetes Association
dc.rights© 2014 by the American Diabetes Association
dc.source.urihttps://doi.org/10.2337/db13-0893
dc.subjectHumans
dc.subjectInsulin
dc.subjectGlucose
dc.subjectBlood Glucose
dc.subjectReceptors, Glucagon
dc.subjectArea Under Curve
dc.subjectCross-Over Studies
dc.subjectDouble-Blind Method
dc.subjectGastric Emptying
dc.subjectMale
dc.subjectGlucagon-Like Peptide 1
dc.subjectYoung Adult
dc.subjectGlucagon-Like Peptide-1 Receptor
dc.titleComparative effects of prolonged and intermittent stimulation of the glucagon- like peptide 1 receptor on gastric emptying and glycemia
dc.typeJournal article
pubs.publication-statusPublished

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