Using high throughput screening to design cell therapy scaffolds /
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(Published version)
Date
2019
Authors
Dalilottojari, Adel
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Type:
thesis
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Abstract
Vessels are dynamic tissues lined with a layer of endothelial cells (ECs) supported by extracellular matrix (ECM) proteins. Endothelial progenitor cells (EPCs) are types of ECs known to play a critical role in the cardiovascular disease treatment as therapeutic agents enhancing endothelium and new vessel formation. However, limited EPC population, hampers its therapeutic use as large yields from cell culture process are required for therapy. This study describes the fabrication of porous silicon-based microparticles (pSi MPs) to support EPC propagation. ECM combinations that enhance EPC isolation/expansion are analysed using a high-throughput screening platform. Significantly higher expansion rate is obtained for EPCs on ECM-immobilised pSi MPs compared to uncoated pSi MPs. This approach provides a higher rate of cell harvesting in shorter periods and increased number of clinical trials.
School/Discipline
University of South Australia. Future Industries Institute.
Future Industries Institute.
Future Industries Institute.
Dissertation Note
Thesis (PhD(Biomaterials Engineering and Nanomedicine))--University of South Australia, 2019.
Provenance
Copyright 2019 Adel Dalilottojari.
Description
1 ethesis (xviii, 174 pages) :
illustrations (some colour), charts (some colour)
Includes bibliographical references.
illustrations (some colour), charts (some colour)
Includes bibliographical references.
Access Status
506 0#$fstar $2Unrestricted online access