Avian riboflavin deficiency: An acquired tomaculous neuropathy
Date
2006
Authors
Cai, Z.
Finnie, J.
Blumbergs, P.
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Journal article
Citation
Veterinary Pathology, 2006; 43(5):780-781
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Abstract
The finding of tomacula, focal areas of sausage-shaped hypermyelination in peripheral nerves, is reported for the first time in avian riboflavin deficiency. Day-old, meat-type chickens were fed a riboflavin-deficient diet (1.8 mg/kg) and were killed on postnatal days 6, 11, 16, and 21, while control chickens were fed a conventional diet containing 5.0 mg/kg riboflavin. Tomacula were found in sciatic and brachial nerves from day 11 onward, became more frequent and prominent with increasing time, and preceded the onset of segmental demyelination.