Pain-causing venom peptides: insights into sensory neuron pharmacology
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Date
2018
Authors
Jami, S.
Erickson, A.
Brierley, S.
Vetter, I.
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Journal article
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Toxins, 2018; 10(1):1-15
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Sina Jami, Andelain Erickson, Stuart M. Brierley and Irina Vetter
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Abstract
Venoms are produced by a wide variety of species including spiders, scorpions, reptiles, cnidarians, and fish for the purpose of harming or incapacitating predators or prey. While some venoms are of relatively simple composition, many contain hundreds to thousands of individual components with distinct pharmacological activity. Pain-inducing or "algesic" venom compounds have proven invaluable to our understanding of how physiological nociceptive neural networks operate. In this review, we present an overview of some of the diverse nociceptive pathways that can be modulated by specific venom components to evoke pain.
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© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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http://purl.org/au-research/grants/nhmrc/1126378
http://purl.org/au-research/grants/nhmrc/1083480
http://purl.org/au-research/grants/nhmrc/1139366
http://purl.org/au-research/grants/nhmrc/1102267
http://purl.org/au-research/grants/nhmrc/1125766
http://purl.org/au-research/grants/nhmrc/1140297
http://purl.org/au-research/grants/arc/FT130101215
http://purl.org/au-research/grants/nhmrc/1083480
http://purl.org/au-research/grants/nhmrc/1139366
http://purl.org/au-research/grants/nhmrc/1102267
http://purl.org/au-research/grants/nhmrc/1125766
http://purl.org/au-research/grants/nhmrc/1140297
http://purl.org/au-research/grants/arc/FT130101215