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Pancreas size and exocrine function is decreased in young children with recent-onset Type 1 diabetes

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dc.contributor.authorAugustine, P.
dc.contributor.authorGent, R.
dc.contributor.authorLouise, J.
dc.contributor.authorTaranto, M.
dc.contributor.authorPenno, M.
dc.contributor.authorLinke, R.
dc.contributor.authorCouper, J.
dc.contributor.authorENDIA Study Group,
dc.date.issued2020
dc.description.abstractAIMS:To measure pancreatic area and exocrine function in young children with recent-onset Type 1 diabetes to determine whether the exocrine pancreas is also affected in the pathophysiology of early childhood diabetes. METHODS:Thirty-two children (14 boys) aged 5.5 (4.5, 7.3) median (IQR) years presenting with recent-onset Type 1 diabetes and 90 controls (44 boys) of similar age had ultrasound imaging of the pancreas. Children with Type 1 diabetes were receiving insulin and were without ketosis. Transverse and longitudinal areas of the pancreas were measured by digitalized outline. Pancreatic faecal elastase-1 was analysed using an enzyme-linked immunosorbent assay kit in recent-onset Type 1 diabetes and 38 first-degree relative control children. RESULTS:Pancreatic area and exocrine function were reduced in Type 1 diabetes. Mean transverse area (SD) in Type 1 diabetes was 6.82 cm2 (1.61) vs. 8.31 cm2 (1.74) in controls, adjusted estimate (95% CI) 1.45 (-2.12, -0.79), P < 0.001; longitudinal area was 1.28 cm2 (0.44) vs. 1.55 cm2 (0.43), adjusted estimate (95% CI) -0.27 (-0.45, -0.09), P = 0.003. Faecal elastase-1 levels in Type 1 diabetes were 455 (323, 833) ug/g, median (IQR) vs. 1408 μg/g (1031, 1989) in controls, P < 0.001. CONCLUSION:Pancreatic area and accompanying subclinical exocrine function were reduced in very young children with recent-onset Type 1 diabetes. This supports changes in the exocrine pancreas in the pathophysiology of Type 1 diabetes presenting in early life.
dc.description.statementofresponsibilityP. Augustine, R. Gent, J. Louise, M. Taranto, M. Penno, R. Linke and J. J. Couper, on behalf of the ENDIA Study Group
dc.identifier.citationDiabetic Medicine, 2020; 37(8):1340-1343
dc.identifier.doi10.1111/dme.13987
dc.identifier.issn0742-3071
dc.identifier.issn1464-5491
dc.identifier.orcidLouise, J. [0000-0001-5785-0290]
dc.identifier.orcidPenno, M. [0000-0002-9617-0826]
dc.identifier.orcidCouper, J. [0000-0003-4448-8629]
dc.identifier.urihttp://hdl.handle.net/2440/119135
dc.language.isoen
dc.publisherWiley
dc.relation.grantNHMRC
dc.rights© 2019 Diabetes UK
dc.source.urihttps://doi.org/10.1111/dme.13987
dc.subjectENDIA Study Group
dc.titlePancreas size and exocrine function is decreased in young children with recent-onset Type 1 diabetes
dc.typeJournal article
pubs.publication-statusPublished

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