The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
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Date
2021
Authors
Modi, N.D.
Tan, J.Q.E.
Rowland, A.
Koczwara, B.
Abuhelwa, A.Y.
Kichenadasse, G.
McKinnon, R.A.
Wiese, M.D.
Sorich, M.J.
Hopkins, A.M.
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npj Breast Cancer, 2021; 7(1):30-
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Abstract
While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive advanced BC (ABC). In the EBC cohort, higher BMI was associated with worse overall survival (OS) (HR [95% CI]: overweight = 1.30 [1.13-1.51]; obese = 1.37 [1.14-1.64], P = < 0.001), and worse disease-free survival (overweight = 1.10 [0.98-1.24]; obese = 1.20 [1.04-1.39], P = 0.061). In contrast, for the ABC cohort, higher BMI was significantly associated with improved OS (overweight = 0.85 [0.76-0.96]; obese = 0.82 [0.72-0.95], P = 0.014), and progression-free survival (overweight = 0.91 [0.83-1.01]; obese = 0.87 [0.77-0.98], P = 0.034). In this large high-quality dataset, higher BMI was independently associated with worse survival in EBC, paradoxically in ABC higher BMI was independently associated with improved survival.
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Data source: Supplementary information, https://doi.org/10.1038/s41523-021-00241-9
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Copyright 2021 The author(s). s This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. (http://creativecommons.org/licenses/by/4.0/)