A diastereoselective synthesis of the tetrahydropyridazinone core of 2-oxo-1,6-diazobicyclo[4.3.0]nonane-9-carboxylate-based peptidomimetics starting from (S)-phenylalanine
Date
2003
Authors
Gardiner, J.
Abell, A.
Editors
Advisors
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Volume Title
Type:
Journal article
Citation
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 2003; 44(22):4227-4230
Statement of Responsibility
James Gardiner and Andrew D. Abell
Conference Name
Abstract
A diastereoseletvive synthesis of a peptidic tetrahydropyridazinone 10 from (S)-phenylalanine is reported. This derivative was then converted to the bicyclic peptidomimetic 11, an important class of β-strand mimetic. © 2003 Elsevier Science Ltd. All rights reserved.