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Key Considerations in Designing Oral Drug Delivery Systems for Dogs

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dc.contributor.authorSong, Y.
dc.contributor.authorPeressin, K.
dc.contributor.authorWong, P.Y.
dc.contributor.authorPage, S.W.
dc.contributor.authorGarg, S.
dc.date.issued2016
dc.description.abstractThe present review discusses the pharmaceutical impact of the anatomy and physiology of the canine gastrointestinal tract to provide a comprehensive guide to the theories and challenges associated with the development of oral drug delivery systems for dogs. Novel pharmaceutical technologies applied to veterinary drugs are discussed indicating the advantages and benefits for animals. There are currently immense research and development efforts being funneled into novel canine health products. Such products are being used to overcome limitations of drugs that display site-dependent absorption or possess poor biopharmaceutical properties. Techniques that are employed to increase bioavailability of the Biopharmaceutics Classification System class II drugs are discussed in this article. Furthermore, an overview of palatable oral formulations for dog care is provided as an approach to easy administration. In vitro and in vivo evaluation and correlation of oral drug formulations in dogs are also addressed. This article assesses the outlook of canine oral drug development recognizing substantial growth forecasts of the dog care market.
dc.identifier.citationJournal of Pharmaceutical Sciences, 2016; 105(5):1576-1585
dc.identifier.doi10.1016/j.xphs.2016.03.007
dc.identifier.issn0022-3549
dc.identifier.issn1520-6017
dc.identifier.orcidGarg, S. [0000-0001-7253-2629]
dc.identifier.urihttps://hdl.handle.net/11541.2/118294
dc.language.isoen
dc.publisherELSEVIER SCIENCE INC
dc.relation.fundingLuoda Pharma
dc.rightsCopyright 2016 American Pharmacists Association. Published by Elsevier Inc Access Condition Notes: Post-print available on Open Access after 1 April 2017
dc.source.urihttps://doi.org/10.1016/j.xphs.2016.03.007
dc.subjectGastrointestinal Tract
dc.subjectAnimals
dc.subjectDogs
dc.subjectPharmaceutical Preparations
dc.subjectDrug Delivery Systems
dc.subjectAdministration, Oral
dc.subjectSpecies Specificity
dc.subjectBiological Availability
dc.subjectGastric Emptying
dc.subjectDrug Design
dc.titleKey Considerations in Designing Oral Drug Delivery Systems for Dogs
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12142951660001831 13142962330001831 Open Access Postprint
ror.mmsid9916038587301831

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