Effect of dietary intervention on human micronucleus frequency in lymphocytes and buccal cells

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dc.contributor.authorThomas, P.
dc.contributor.authorWu, J.
dc.contributor.authorDhillon, V.
dc.contributor.authorFenech, M.
dc.date.issued2011
dc.description.abstractSuccessful maintenance of accurate DNA replication and repair is critical to human health. Once this homeostatic balance is impaired, genomic instability events occur, compromising the integrity of the genome, which may initiate fundamental events leading to human diseases. Biomarkers of DNA damage, such as the micronucleus (MN) index, are elevated both in developmental and degenerative diseases and have been shown to be predictive of increased cancer risk and cardiovascular disease mortality. Several micronutrients have been identified as being effective in reducing and/or protecting against DNA damage. Micronutrients act as co-factors for enzymes required in DNA repair or maintenance of methylation patterns essential for optimal gene expression. In this review, published human intervention studies are examined with respect to the efficacy of micronutrient supplementation in reducing MN frequency in both lymphocytes and buccal cells. Important knowledge gaps and future research directions are also explored. The outcomes of these studies suggest that supplementation with antioxidant vitamins and certain B vitamins may cause a substantial reduction in MN frequency.
dc.description.statementofresponsibilityPhilip Thomas, Jing Wu, Varinderpal Dhillon and Michael Fenech
dc.identifier.citationMutagenesis, 2011; 26(1):69-76
dc.identifier.doi10.1093/mutage/geq072
dc.identifier.issn0267-8357
dc.identifier.issn1464-3804
dc.identifier.orcidWu, J. [0000-0002-1554-9798]
dc.identifier.orcidFenech, M. [0000-0002-8466-0991]
dc.identifier.urihttp://hdl.handle.net/2440/71833
dc.language.isoen
dc.publisherOxford Univ Press
dc.rightsThe Author 2010. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved.
dc.source.urihttps://doi.org/10.1093/mutage/geq072
dc.subjectMouth Mucosa
dc.subjectLymphocytes
dc.subjectMicronuclei, Chromosome-Defective
dc.subjectHumans
dc.subjectDNA Damage
dc.subjectAntioxidants
dc.subjectDiet
dc.subjectMicronucleus Tests
dc.subjectFeeding Behavior
dc.subjectGene Expression
dc.subjectClinical Trials as Topic
dc.titleEffect of dietary intervention on human micronucleus frequency in lymphocytes and buccal cells
dc.typeJournal article
pubs.publication-statusPublished

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