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Using vaginal Group B Streptococcus colonisation in women with preterm premature rupture of membranes to guide the decision for immediate delivery: a secondary analysis of the PPROMEXIL trials

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dc.contributor.authorTajik, P.
dc.contributor.authorvan der Ham, D.
dc.contributor.authorZafarmand, M.
dc.contributor.authorHof, M.
dc.contributor.authorMorris, J.
dc.contributor.authorFranssen, M.
dc.contributor.authorde Groot, C.
dc.contributor.authorDuvekot, J.
dc.contributor.authorOudijk, M.
dc.contributor.authorWillekes, C.
dc.contributor.authorBloemenkamp, K.
dc.contributor.authorPorath, M.
dc.contributor.authorWoiski, M.
dc.contributor.authorAkerboom, B.
dc.contributor.authorSikkema, J.
dc.contributor.authorBijvank, B.
dc.contributor.authorMulder, A.
dc.contributor.authorBossuyt, P.
dc.contributor.authorMol, B.
dc.date.issued2014
dc.descriptionArticle first published online: 27 MAY 2014
dc.description.abstractOBJECTIVE: To investigate whether vaginal Group B Streptococcus (GBS) colonisation or other baseline characteristics of women with preterm premature rupture of membranes (PPROM) can help in identifying subgroups of women who would benefit from immediate delivery. DESIGN: Secondary analysis of the PPROMEXIL trials. SETTING: Sixty hospitals in the Netherlands. POPULATION: Women with PPROM between 34 and 37 weeks of gestation. METHODS: Random assignment of 723 women to immediate delivery or expectant management. MAIN OUTCOME MEASURES: Early onset neonatal sepsis. RESULTS: Vaginal GBS colonisation status was the only marker which was significantly associated with the benefit of immediate delivery (P for interaction: 0.04). GBS colonisation was observed in 14% of women. The risk of early onset neonatal sepsis in GBS-positive women was high (15.2%) when they were managed expectantly but this risk was reduced to 1.8% with immediate delivery. The early onset neonatal sepsis risk was much lower in neonates of GBS-negative women: 2.6% after expectant management and 2.9% with immediate delivery. We estimated that by inducing labour only in GBS-positive women, there would be a 10.4% increase in term delivery rate, while keeping neonatal sepsis and caesarean delivery rates comparable to a strategy of labour induction for all. CONCLUSIONS: Our post hoc findings suggest that women with PROM between 34 and 37 weeks might benefit from immediate delivery if they have GBS vaginal colonisation, while in GBS-negative women labour induction could be delayed until 37 weeks.
dc.description.statementofresponsibilityP Tajik, DP van der Ham, MH Zafarmand, MHP Hof, J Morris, MTM Franssen, CJM de Groot, JJ Duvekot, MA Oudijk, C Willekes, KWM Bloemenkamp, M Porath, M Woiski, BM Akerboom, JM Sikkema, B Nij Bijvank, ALM Mulder, PM Bossuyt, BWJ Mol
dc.identifier.citationBJOG: An International Journal of Obstetrics and Gynaecology, 2014; 121(10):1263-1272
dc.identifier.doi10.1111/1471-0528.12889
dc.identifier.issn1470-0328
dc.identifier.issn1471-0528
dc.identifier.orcidMol, B. [0000-0001-6887-0262] [0000-0001-8337-550X]
dc.identifier.urihttp://hdl.handle.net/2440/97508
dc.language.isoen
dc.publisherWiley
dc.rights© 2014 Royal College of Obstetricians and Gynaecologists
dc.source.urihttps://doi.org/10.1111/1471-0528.12889
dc.subjectEarly onset neonatal sepsis; group B streptococcus; preterm premature rupture of membranes; treatment selection marker; vaginal culture
dc.titleUsing vaginal Group B Streptococcus colonisation in women with preterm premature rupture of membranes to guide the decision for immediate delivery: a secondary analysis of the PPROMEXIL trials
dc.typeJournal article
pubs.publication-statusPublished

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