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Identifying research priorities for cognition in CKD : a Delphi Study

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dc.contributor.authorAlexiuk, J.
dc.contributor.authorHarasemiw, O.
dc.contributor.authorVanderlinden, J.
dc.contributor.authorVerrelli, D.
dc.contributor.authorTarca, B.
dc.contributor.authorCollister, D.
dc.contributor.authorRibeiro, H.
dc.contributor.authorCorradetti, B.
dc.contributor.authorFowler, K.
dc.contributor.authorMcAdams Demarco, M.
dc.contributor.authorChu, N.
dc.contributor.authorJesudason, S.
dc.contributor.authorMcKeaveney, C.
dc.contributor.authorLeon, S.J.
dc.contributor.authorAnandh, U.
dc.contributor.authorTollitt, J.
dc.contributor.authorThompson, S.
dc.contributor.authorDasgupta, I.
dc.contributor.authorBohm, C.
dc.date.issued2025
dc.description.abstractBackground: Cognition is a research priority for people living with chronic kidney disease (CKD), but identification of critical research questions is lacking. This study aimed to determine which cognition-related research questions are most important to CKD stakeholders. Methods: A modified Delphi technique with 3 survey rounds was used. The study sample included 3 panels (People with lived CKD experience, Researchers, and Clinicians) recruited through international patient and kidney research networks, kidney societies, and snowball sampling with email invitations. Survey rounds were distributed electronically through REDCap. In Round 1 (October 2021-May 2022), respondents contributed three important research questions regarding cognition in CKD (free text). After deduplication and qualitative synthesis, respondents ranked the importance of these questions on a nine-point Likert scale in Round 2 (Feb-April 2023). Questions with mean and median ratings of >7 by at least two respondent panels or rated critically important by the ‘lived experience’ panel were re-ranked in Round 3 ( Aug-Sept 2023) and assessed for consensus to identify the final list of priority research questions. Results: Respondents (n=152) identified 125 and 44 discrete questions after Rounds 1 and 2, respectively. The final shortlist included 27 questions in 8 categories. The most critical research question identified was “What factors prevent cognitive impairment in people receiving dialysis?” Overall, respondents prioritized questions focusing on prevention and treatment of cognitive impairment. Scores between the panels were significantly different for 16 questions. Those with lived CKD experience prioritized quality of life, researchers emphasized developing interventions to mitigate cognitive impairment, and clinicians prioritized the effect of CKD treatment on cognitive impairment. Conclusions: Through an established consensus methodology involving key stakeholder groups, we identified 27 critical research questions about cognition in CKD. These questions should guide future study design and outcome selection.
dc.identifier.citationKidney360, 2025; 6(5):739-753
dc.identifier.doi10.34067/KID.0000000708
dc.identifier.issn2641-7650
dc.identifier.issn2641-7650
dc.identifier.orcidTarca, B. [0000-0002-3807-8298]
dc.identifier.orcidJesudason, S. [0000-0001-9695-0761]
dc.identifier.urihttps://hdl.handle.net/11541.2/41790
dc.language.isoen
dc.publisherWolters Kluwer Health
dc.relation.fundingCanadian Institutes of Health Research
dc.relation.fundingFresenius Canada
dc.relation.fundingSanofi and Baxter
dc.relation.fundingFAPDF
dc.rightsCopyright 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology. This is an open access article distributed under the terms of the Creative Commons AttributionNonCommercial-NoDerivatives License 4.0 (CC-BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or commercially without permission from the journal. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.source.urihttps://doi.org/10.34067/KID.0000000708
dc.subjectchronic kidney disease
dc.subjectCKD
dc.subjectcognitive impairment
dc.titleIdentifying research priorities for cognition in CKD : a Delphi Study
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916940330401831

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