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Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues

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dc.contributor.authorXiong, J.
dc.contributor.authorZhou, L.
dc.contributor.authorLim, Y.
dc.contributor.authorYang, M.
dc.contributor.authorZhu, Y.
dc.contributor.authorWei Li, Z.
dc.contributor.authorFu, D.
dc.contributor.authorZhou, X.
dc.date.issued2015
dc.description.abstractThere are two forms of brain-derived neurotrophic factor (BDNF), precursor of BDNF (proBDNF) and mature BDNF, which each exert opposing effects through two different transmembrane receptor signaling systems, consisting of p75 neurotrophin receptor (p75NTR) and tyrosine receptor kinase B (TrkB). Previous studies have demonstrated that proBDNF promotes cell death and inhibits the growth and migration of C6 glioma cells through p75NTR in vitro, while mature BDNF has opposite effects on C6 glioma cells. It is hypothesized that mature BDNF is essential in the development of malignancy in gliomas. However, histological data obtained in previous studies were unable distinguish mature BDNF from proBDNF due to the lack of specific antibodies. The present study investigated the expression of mature BDNF using a specific sheep monoclonal anti-mature BDNF antibody in 42 human glioma tissues of different grades and 10 control tissues. The correlation between mature BDNF and TrkB was analyzed. Mature BDNF expression was significantly increased in high-grade gliomas, and was positively correlated with the malignancy of the tumor and TrkB receptor expression. The present data have demonstrated that increased levels of mature BDNF contribute markedly to the development of malignancy of human gliomas through the primary BDNF receptor TrkB.
dc.identifier.citationOncology Letters, 2015; 10(1):223-227
dc.identifier.doi10.3892/ol.2015.3181
dc.identifier.issn1792-1074
dc.identifier.issn1792-1082
dc.identifier.orcidLim, Y. [0000-0003-1110-1969]
dc.identifier.orcidZhou, X. [0000-0002-8687-0175]
dc.identifier.urihttps://hdl.handle.net/11541.2/119605
dc.language.isoen
dc.publisherSPANDIDOS PUBL LTD
dc.rightsCopyright Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.source.urihttps://doi.org/10.3892/ol.2015.3181
dc.subjectbrain-derived neurotrophic factor
dc.subjectglioma
dc.subjecthuman
dc.subjecttyrosine receptor kinase B
dc.titleMature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915989398201831

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