Punctal-canalicular stenosis associated with mitomycin-C for corneal epithelial dysplasia

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dc.contributor.authorBilling, K.
dc.contributor.authorKaragiannis, A.
dc.contributor.authorSelva-Nayagam, D.
dc.date.issued2003
dc.description.abstract<h4>Purpose</h4>To report a case of punctal-canalicular stenosis after topical mitomycin C use for corneal dysplasia. To the authors' knowledge, this association has not previously been described.<h4>Design</h4>Observational case report.<h4>Method</h4>A 62-year-old woman was noted to have a right inferotemporal corneal dysplastic lesion. She received a topical course of mitomycin-C 0.04% four times a day, which subsequently invoked a toxoallergic reaction. One month later, the patient developed right-sided epiphora.<h4>Results</h4>Probing demonstrated complete stenosis of the right lower canaliculus, 5 mm from the punctum.<h4>Conclusion</h4>Mitomycin-C use may lead to lacrimal apparatus fibrosis and symptomatic epiphora when inciting a toxoallergic reaction.
dc.description.statementofresponsibilityKathryn Billing, Arthur Karagiannis and Dinesh Selva
dc.identifier.citationAmerican Journal of Ophthalmology, 2003; 136(4):746-747
dc.identifier.doi10.1016/S0002-9394(03)00393-3
dc.identifier.issn0002-9394
dc.identifier.issn1879-1891
dc.identifier.orcidSelva-Nayagam, D. [0000-0002-2169-5417]
dc.identifier.urihttp://hdl.handle.net/2440/54991
dc.language.isoen
dc.publisherElsevier Science Inc
dc.source.urihttps://doi.org/10.1016/s0002-9394(03)00393-3
dc.subjectNasolacrimal Duct
dc.subjectHumans
dc.subjectCorneal Diseases
dc.subjectLacrimal Duct Obstruction
dc.subjectFibrosis
dc.subjectMitomycin
dc.subjectAntibiotics, Antineoplastic
dc.subjectAdministration, Topical
dc.subjectMiddle Aged
dc.subjectFemale
dc.titlePunctal-canalicular stenosis associated with mitomycin-C for corneal epithelial dysplasia
dc.typeJournal article
pubs.publication-statusPublished

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