Idiopathic dacryoadenitis: clinical features, histopathology, and treatment outcomes
Date
2016
Authors
Andrew, N.H.
Kearney, D.
Sladden, N.
McKelvie, P.
Wu, A.
Sun, M.T.
McNab, A.
Selva, D.
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Journal article
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American Journal of Ophthalmology, 2016; 163:148-153.e1
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Nicholas H. Andrew, Daniel Kearney, Nicole Sladden, Penny McKelvie, Albert Wu, Michele T. Sun, Alan McNab and Dinesh Selva
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Abstract
Purpose: To review the clinical and histologic features of idiopathic dacryoadenitis, and to assess prognostic factors associated with disease recurrence, treatment recalcitrance, and incomplete treatment response. Design: Retrospective interventional case series. Methods: setting: Tertiary referral centers. patients: Seventy-nine cases of biopsy-confirmed idiopathic dacryoadenitis. observation procedures: The following data were reviewed: age, sex, laterality, symptom onset, clinical presentation, histopathology, treatment response, and recurrence. main outcome measures: Rates of treatment recalcitrance, incomplete treatment response, and recurrence. Results: Idiopathic dacryoadenitis patients had a mean age of 50 years, 57% were female, and 16% of cases were bilateral. Fifty-two percent had inflammation extending to adjacent structures on imaging. Twenty percent were recalcitrant to treatment, 17% had an incomplete treatment response, and 15% of patients had a recurrence during a mean follow-up time of 64 months. Risk factors for an incomplete treatment response were male sex (P = .01) and inflammation extending to extraocular muscle (P = .01). A clinical presentation of "classic" dacryoadenitis was a risk factor for treatment recalcitrance (P = .02). Bilateral cases were younger than unilateral cases (P = .004) and had an increased risk of recurrence (P = .05). Sclerosing cases were associated with an insidious onset of symptoms (P = .009), but neither histopathology nor the speed of symptom onset was associated with a poor prognosis. Conclusion: Thirty-seven percent of idiopathic dacryoadenitis had a poor response to treatment and 15% of cases recurred. The prognostic factors identified in this study have not been reported previously and may inform management.
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© 2016 Elsevier Inc. All rights reserved.