Determinants of Perinatal Outcomes in Dialyzed and Transplanted Women in Australia

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dc.contributor.authorHewawasam, E.
dc.contributor.authorDavies, C.E.
dc.contributor.authorLi, Z.
dc.contributor.authorClayton, P.
dc.contributor.authorSullivan, E.
dc.contributor.authorMcDonald, S.P.
dc.contributor.authorJesudason, S.
dc.date.issued2022
dc.description.abstractIntroduction: Drivers of adverse perinatal outcomes in pregnancies of women receiving chronic kidney replacement therapy (KRT) remain poorly understood. Methods: Births ≥ 20 weeks of gestation in Australian women receiving KRT were analyzed for perinatal outcomes stratified by maternal KRT exposure (dialysis or transplant, analyzed separately), by linking the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) and perinatal data sets (1991–2013). Results: Of 2,948,084 babies (1,628,181 mothers), 248 were born to mothers receiving KRT (transplant, n ₌ 211; dialysis, n ₌ 37), with live birth rates ≥ 94%. The perinatal death rate was 162, 62, and 9 per 1000 births in the dialysis, transplant, and non-KRT cohorts, respectively. Babies exposed to KRT had increased odds of prematurity, small-for-gestational age (SGA), poor birth condition, resuscitation, intensive care admission, and longer hospitalization, with the dialysis cohort having worse outcomes. Preterm babies of dialyzed and transplanted mothers (compared with preterm babies with no KRT exposure) experienced 1.6- to 2.7-fold higher odds for all adverse outcomes, except birthweight < 2500 g, which was 11-fold higher for the dialysis cohort. In adjusted analyses, transplanted women with better allograft function (serum creatinine ≤120 mmol/l) still had >10-fold higher odds of preterm birth and low birthweight and 1.8- to 4.6-fold increased odds of other adverse outcomes. In transplanted women, mediation analysis revealed that pregnancy-induced hypertension contributed only a modest proportional effect (2.5%–11.2%) on adverse outcomes. Conclusion: Maternal dialysis and transplantation conferred excess perinatal morbidity, particularly for preterm babies, and even in women with good preconception allograft function. Pregnancy-induced hypertension is not the predominant determinant of perinatal morbidity. Preconception counseling of women with kidney disease should encompass discussion of perinatal complications.
dc.description.statementofresponsibilityErandi Hewawasam, Christopher E. Davies, Zhuoyang Li, Philip Clayton, Elizabeth Sullivan, Stephen P. McDonald, and Shilpanjali Jesudason
dc.identifier.citationKidney International Reports, 2022; 7(6):1318-1331
dc.identifier.doi10.1016/j.ekir.2022.03.015
dc.identifier.issn2468-0249
dc.identifier.issn2468-0249
dc.identifier.orcidHewawasam, E. [0000-0002-8320-3668]
dc.identifier.orcidDavies, C.E. [0000-0001-6595-8656]
dc.identifier.orcidClayton, P. [0000-0001-9190-6753]
dc.identifier.orcidMcDonald, S.P. [0000-0001-6103-1386]
dc.identifier.orcidJesudason, S. [0000-0001-9695-0761]
dc.identifier.urihttps://hdl.handle.net/2440/136341
dc.language.isoen
dc.publisherElsevier BV
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1092957
dc.rightsCrown Copyright © 2022, Published by Elsevier Inc. on behalf of the International Society of Nephrology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.source.urihttps://doi.org/10.1016/j.ekir.2022.03.015
dc.subjectdialysis; fetal; kidney failure; maternal; perinatal; pregnancy; transplant
dc.titleDeterminants of Perinatal Outcomes in Dialyzed and Transplanted Women in Australia
dc.typeJournal article
pubs.publication-statusPublished

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