Mapping and ablation of polymorphic ventricular tachycardia after myocardial infarction

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dc.contributor.authorSzumowski, L.
dc.contributor.authorSanders, P.
dc.contributor.authorWalczak, F.
dc.contributor.authorHocini, M.
dc.contributor.authorJais, P.
dc.contributor.authorKepski, R.
dc.contributor.authorSzufladowicz, E.
dc.contributor.authorUrbanek, P.
dc.contributor.authorDerejko, P.
dc.contributor.authorBodalski, R.
dc.contributor.authorHaissaguerre, M.
dc.date.issued2004
dc.description.abstractObjectives The goal of this study was to describe the mapping and ablation of polymorphic ventricular tachycardia (VT) after myocardial infarction (MI). Background The initiating mechanisms of polymorphic VT after MI have not been reported. Methods Five patients (four males; age 61 ± 7 years) with recurrent episodes of polymorphic VT after anterior MI (left ventricular ejection fraction 32 ± 7%) despite revascularization and antiarrhythmic drugs were studied. All patients demonstrated frequent ventricular premature beats (PBs) initiating polymorphic VT. Pace mapping and activation mapping were used to identify the earliest site of PB activity. The presence of a Purkinje potential preceding PB defined its origin from the Purkinje network. Electroanatomic voltage mapping was performed to delineate the extent of MI. Results The PBs were observed in all cases to arise from the Purkinje arborization in the MI border zone. These PBs were right bundle-branch block in all five patients, with morphologic variations in the limb leads in four; one also had a left bundle-branch block morphology. The coupling interval of the PB to the preceding QRS complex demonstrated significant variations (320 to 600 ms). During PB, the Purkinje potential at the same site preceded the QRS complex by 20 to 160 ms and was associated with different morphologies. Repetitive Purkinje activity was documented during polymorphic VT. Splitting of Purkinje activity and Purkinje to muscle conduction block were also observed. Ablation at these sites eliminated all PBs. At 16 ± 5 months follow-up using defibrillator memory interrogation, no patient has had recurrence of arrhythmia. Conclusions The Purkinje arborization along the border-zone of scar has an important role in the mechanism of polymorphic VT in patients after MI. Ablation of the local Purkinje network allows suppression of polymorphic VT.
dc.description.statementofresponsibilityLukasz Szumowski, Prashanthan Sanders, Franciszek Walczak, Mélèze Hocini, Pierre Jaïs, Roman Kepski, Ewa Szufladowicz, Piotr Urbanek, Paweł Derejko, Robert Bodalski and Michel Haïssaguerre
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/505766/description#description
dc.identifier.citationJournal of the American College of Cardiology, 2004; 44(8):1700-1706
dc.identifier.doi10.1016/j.jacc.2004.08.034
dc.identifier.issn0735-1097
dc.identifier.issn1558-3597
dc.identifier.orcidSanders, P. [0000-0003-3803-8429]
dc.identifier.urihttp://hdl.handle.net/2440/39210
dc.language.isoen
dc.publisherElsevier Science Inc
dc.rights© 2004 American College of Cardiology Foundation. Published by Elsevier Inc.
dc.source.urihttps://doi.org/10.1016/j.jacc.2004.08.034
dc.subjectPurkinje Fibers
dc.subjectHumans
dc.subjectVentricular Premature Complexes
dc.subjectBundle-Branch Block
dc.subjectTachycardia, Ventricular
dc.subjectMyocardial Infarction
dc.subjectVentricular Dysfunction, Left
dc.subjectPostoperative Complications
dc.subjectAnti-Arrhythmia Agents
dc.subjectUltrasonography, Interventional
dc.subjectElectrocardiography
dc.subjectCatheter Ablation
dc.subjectCoronary Artery Bypass
dc.subjectSignal Processing, Computer-Assisted
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectHemodynamics
dc.subjectSecondary Prevention
dc.titleMapping and ablation of polymorphic ventricular tachycardia after myocardial infarction
dc.typeJournal article
pubs.publication-statusPublished

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