Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages"

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dc.contributor.authorWatkins, L.
dc.contributor.authorHutchinson, M.
dc.contributor.authorJohnson, K.
dc.date.issued2012
dc.description.abstractLandry et al. provide a 2-part study. Part 1 reports the failure of propentofylline to show reduced pain in patients with post-herpetic neuralgia. Part 2 reports cell culture results for macrophages and microglia. Comments regarding each are provided below. Such significant concepts to the field of translational validity of glial cell modulation and related pharmacotherapy as reported in Landry et al. warrant higher standards of study design and data presentation than their paper affords.
dc.description.statementofresponsibilityLinda R. Watkins, Mark R. Hutchinson, Kirk W. Johnson
dc.identifier.citationExperimental Neurology, 2012; 234(2):351-353
dc.identifier.doi10.1016/j.expneurol.2012.01.006
dc.identifier.issn0014-4886
dc.identifier.issn1090-2430
dc.identifier.orcidHutchinson, M. [0000-0003-2154-5950]
dc.identifier.urihttp://hdl.handle.net/2440/74366
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.rights© 2012 Elsevier Inc. All rights reserved
dc.source.urihttps://doi.org/10.1016/j.expneurol.2012.01.006
dc.subjectFETAL
dc.subjectNeuralgia
dc.subjectPostherpetic - drug therapy
dc.subjectMacrophages - drug effects
dc.subjectBRAIN
dc.subjectMicroglia - drug effects
dc.titleCommentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages"
dc.typeJournal article
pubs.publication-statusPublished

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