Integration of enzyme immobilised single-walled carbon nanotube arrays into microchannels for glucose detection

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dc.contributor.authorYu, J.
dc.contributor.authorMatthews, S.
dc.contributor.authorYunus, K.
dc.contributor.authorShapter, J.
dc.contributor.authorFisher, A.
dc.date.issued2013
dc.description.abstractMicrofluidic devices for glucose detection have been constructed and developed by integration of covalently immobilised single-walled carbon nanotube arrays functionalised with glucose oxidase into a poly (dimethylsiloxane)-based microfluidic channel. With biocompatible ferrocenecarboxylic acid as electron transfer mediator, these microfluidic devices were tested systematically for electrochemical glucose detection by changing some geometrical parameters such as the width of detecting electrode as well as electrode gap between the enzyme electrode and the detecting electrode. Numerical simulations were also carried out using a finite difference model and used to further understand the concentration profiles in michochannels. The experimental results showed that glucose can be detected with a linear response up to a concentration of 5 mmol L⁻¹. Compared to reported glucose detection techniques, our microfluidic devices have some advantages such as simple design, repeated use and low cost.
dc.description.statementofresponsibilityJingxian Yu, Sinéad M Matthews, Kamran Yunus, Joseph G Shapter and Adrian C Fisher
dc.identifier.citationInternational Journal of Electrochemical Science, 2013; 8(2):1849-1862
dc.identifier.issn1452-3981
dc.identifier.issn1452-3981
dc.identifier.orcidYu, J. [0000-0002-6489-5988]
dc.identifier.urihttp://hdl.handle.net/2440/78413
dc.language.isoen
dc.publisherElectrochemical Science Group
dc.relation.granthttp://purl.org/au-research/grants/arc/DP0985176
dc.relation.granthttp://purl.org/au-research/grants/arc/DP0985176
dc.rights© 2013 by ESG (www.electrochemsci.org)
dc.source.urihttp://www.electrochemsci.org/papers/vol8/80201849.pdf
dc.subjectMicrofluidic devices
dc.subjectglucose oxidase
dc.subjectcarbon nanotube arrays
dc.subjectglucose detection
dc.subjectferrocenecarboxylic acid
dc.titleIntegration of enzyme immobilised single-walled carbon nanotube arrays into microchannels for glucose detection
dc.typeJournal article
pubs.publication-statusPublished

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