ARDent about acetylation and deacetylation in hypoxia signalling
| dc.contributor.author | Bilton, Rebecca Louise | en |
| dc.contributor.author | Trottier, Eric | en |
| dc.contributor.author | Pouyssegur, Jacques | en |
| dc.contributor.author | Brahimi-Horn, M. Christiane | en |
| dc.contributor.organisation | Centre for the Molecular Genetics of Development | en |
| dc.contributor.school | School of Molecular and Biomedical Science | en |
| dc.date.issued | 2006 | en |
| dc.description | Copyright © 2006 Elsevier Ltd All rights reserved. | en |
| dc.description.abstract | Given the key role that the α subunit of the αβ heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1) has in tumourigenesis, and in particular in angiogenesis, a full understanding of its regulation is crucial to the development of cancer therapeutics. Posttranslational acetylation and deacetylation of this subunit by an acetyltransferase called Arrest-defective-1 (ARD1) and by different histone deacetylases (HDACs), respectively, has been suggested as a mechanism. However, conflicting data bring into question the foundations of this mechanism and at present it is not clear what the precise role of these proteins is with respect to HIF. Nonetheless, the observation that small-molecule inhibitors of HDACs have anti-angiogenic activity suggests that acetylation and deacetylation of HIF or HIF modifiers represents a potential target in cancer therapy. | en |
| dc.description.statementofresponsibility | Rebecca Bilton, Eric Trottier, Jacques Pouysségur and M. Christiane Brahimi-Horn | en |
| dc.description.uri | http://www.sciencedirect.com/science/journal/09628924 | en |
| dc.identifier.citation | Trends in Cell Biology, 2006; 16(12):616-621 | en |
| dc.identifier.doi | 10.1016/j.tcb.2006.10.002 | en |
| dc.identifier.issn | 0962-8924 | en |
| dc.identifier.uri | http://hdl.handle.net/2440/35547 | |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | en |
| dc.title | ARDent about acetylation and deacetylation in hypoxia signalling | en |
| dc.type | Journal article | en |