14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain

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dc.contributor.authorToyo-oka, K.
dc.contributor.authorWachi, T.
dc.contributor.authorHunt, R.F.
dc.contributor.authorBaraban, S.C.
dc.contributor.authorTaya, S.
dc.contributor.authorRamshaw, H.
dc.contributor.authorKaibuchi, K.
dc.contributor.authorSchwarz, Q.P.
dc.contributor.authorLopez, A.F.
dc.contributor.authorWynshaw-Boris, A.
dc.date.issued2014
dc.description.abstractDuring brain development, neural progenitor cells proliferate and differentiate into neural precursors. These neural precursors migrate along the radial glial processes and localize at their final destination in the cortex. Numerous reports have revealed that 14-3-3 proteins are involved in many neuronal activities, although their functions in neurogenesis remain unclear. Here, using 14-3-3ε/ζ double knock-out mice, we found that 14-3-3 proteins are important for proliferation and differentiation of neural progenitor cells in the cortex, resulting in neuronal migration defects and seizures. 14-3-3 deficiency resulted in the increase of δ-catenin and the decrease of β-catenin and αN-catenin. 14-3-3 proteins regulated neuronal differentiation into neurons via direct interactions with phosphorylated δ-catenin to promote F-actin formation through a catenin/Rho GTPase/Limk1/cofilin signaling pathway. Conversely, neuronal migration defects seen in the double knock-out mice were restored by phosphomimic Ndel1 mutants, but not δ-catenin. Our findings provide new evidence that 14-3-3 proteins play important roles in neurogenesis and neuronal migration via the regulation of distinct signaling cascades.
dc.description.statementofresponsibilityKazuhito Toyo-oka, Tomoka Wachi, Robert F. Hunt, Scott C. Baraban, Shinichiro Taya, Hayley Ramshaw, Kozo Kaibuchi, Quenten P. Schwarz, Angel F. Lopez and Anthony Wynshaw-Boris
dc.identifier.citationThe Journal of Neuroscience, 2014; 34(36):12168-12181
dc.identifier.doi10.1523/JNEUROSCI.2513-13.2014
dc.identifier.issn0270-6474
dc.identifier.issn1529-2401
dc.identifier.orcidRamshaw, H. [0000-0001-9909-282X]
dc.identifier.orcidLopez, A.F. [0000-0001-7430-0135]
dc.identifier.urihttp://hdl.handle.net/2440/91428
dc.language.isoen
dc.publisherSociety for Neuroscience
dc.rights© 2014 the authors. Authors grant JNeurosci a license to publish their work and copyright remains with the author. Material published from 2010 to 2014 is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License (CC-BY-NC-SA).
dc.source.urihttps://doi.org/10.1523/jneurosci.2513-13.2014
dc.subject14-3-3; delta-catenin; neurogenesis; neuronal differentiation; neuronal migration
dc.title14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain
dc.title.alternative14-3-3epsilon and zeta regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain
dc.typeJournal article
pubs.publication-statusPublished

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