Efficacy and safety of colchicine for the treatment of osteoarthritis: a systematic review and meta-analysis of intervention trials

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dc.contributor.authorSingh, A.
dc.contributor.authorMolina-Garcia, P.
dc.contributor.authorHussain, S.
dc.contributor.authorPaul, A.
dc.contributor.authorDas, S.K.
dc.contributor.authorLeung, Y.Y.
dc.contributor.authorHill, C.L.
dc.contributor.authorDanda, D.
dc.contributor.authorSamuels, J.
dc.contributor.authorAntony, B.
dc.date.issued2022
dc.description.abstractObjective: Colchicine, an approved treatment for gout, has been trialed in many diseases including osteoarthritis (OA) due to its anti-inflammatory effects. However, its efficacy and safety remain unclear in OA. This systematic review and meta- analysis evaluated the efficacy and safety of colchicine for the treatment of OA. Methods: PubMed, Web of Science, Scopus, and Cochrane Central were searched from inception through September 2022. Two reviewers independently screened for randomized controlled trials (RCTs) comparing colchicine with placebo or other active comparators for the treatment of OA (knee, hand, or hip OA), extracted data, and performed Cochrane risk of bias assessments. Result: Nine RCTs for the knee OA and one for the hand OA were identified, consisting of 847 patients (429 in colchicine arms, 409 in control arms). The studies were conducted between 2002 and 2021 with follow-up periods ranging from 2 to 12 months, in India, Iran, Turkey, Australia, Singapore, and Iraq. Moderate-quality evidence showed no clinically important pain reduction with colchicine compared to control (standardized mean difference [SMD], 0.17; 95% confidence interval [CI], − 0.55, 0.22). Moderate-quality evidence showed no improvement in function with colchicine compared to control in knee OA patients (SMD, − 0.37; 95% CI, − 0.87, 0.13). Colchicine showed an acceptable safety profile with AEs/SAEs comparable to control. Conclusion: Current evidence does not suggest a benefit of colchicine in reducing pain and improving physical function in the overall cohort of hand/knee OA patients. Future trials should focus on the subgroups of OA patients with local or systemic inflammation and/or mineralization who might benefit from colchicine.
dc.description.statementofresponsibilityAmbrish Singh, Pablo Molina, Garcia, Salman Hussain, Alok Paul, Siddharth Kumar Das, Ying-Ying Leung, Catherine L. Hill, Debashish Danda, Jonathan Samuels, Benny Antony
dc.identifier.citationClinical Rheumatology, 2022; 42(3):889-902
dc.identifier.doi10.1007/s10067-022-06402-w
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.orcidHill, C.L. [0000-0001-8289-4922]
dc.identifier.urihttps://hdl.handle.net/2440/139048
dc.language.isoen
dc.publisherSpringer Link
dc.relation.grantNHMRC
dc.rights© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.source.urihttps://doi.org/10.1007/s10067-022-06402-w
dc.subjectCalcium pyrophosphate
dc.subjectChondrocalcinosis
dc.subjectColchicine
dc.subjectOsteoarthritis
dc.subjectOsteoarthritis knee
dc.subject.meshKnee Joint
dc.subject.meshHumans
dc.subject.meshOsteoarthritis, Knee
dc.subject.meshOsteoarthritis, Hip
dc.subject.meshPain
dc.subject.meshColchicine
dc.titleEfficacy and safety of colchicine for the treatment of osteoarthritis: a systematic review and meta-analysis of intervention trials
dc.typeJournal article
pubs.publication-statusPublished

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