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Interaction of terbinafine (anti-fungal agent) with perhexiline: a case report

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dc.contributor.authorSheikh, A.R.
dc.contributor.authorWestley, I.
dc.contributor.authorSallustio, B.
dc.contributor.authorHorowitz, J.D.
dc.contributor.authorBeltrame, J.F.
dc.date.issued2014
dc.description.abstractPerhexiline is a unique anti-anginal agent that is frequently used in the treatment of chronic refractory angina. Its utility has been limited because of its complex pharmacokinetics that were only appreciated following the development of a therapeutic perhexiline assay. Perhexiline is cleared primarily via formation of mono-hydroxy metabolites (OH-perhexiline) by cytochrome P450 2D6 (CYP2D6). Drugs that are inhibitors of CYP2D6 may therefore inhibit perhexiline metabolism, increase plasma perhexiline concentration and may consequently increase the risk of toxicity. We report a case of a rise in perhexiline plasma concentration to a toxic level following the introduction of terbinafine hydrochloride; a moderate CYP2D6 inhibiting drug.
dc.description.statementofresponsibilityAbdul Rauf Sheikh, Ian Westley, Benedetta Sallustio, John D Horowitz, John F Beltrame
dc.identifier.citationHeart Lung and Circulation, 2014; 23(6):e149-e151
dc.identifier.doi10.1016/j.hlc.2013.11.012
dc.identifier.issn1443-9506
dc.identifier.issn1444-2892
dc.identifier.orcidSheikh, A.R. [0000-0003-2767-7890]
dc.identifier.orcidSallustio, B. [0000-0002-0186-3073]
dc.identifier.orcidHorowitz, J.D. [0000-0001-6883-0703]
dc.identifier.orcidBeltrame, J.F. [0000-0002-4294-6510]
dc.identifier.urihttp://hdl.handle.net/2440/97295
dc.language.isoen
dc.publisherElsevier
dc.rightsCrown Copyright © 2013
dc.source.urihttps://doi.org/10.1016/j.hlc.2013.11.012
dc.subjectPerhexiline
dc.subjectTerbinafine
dc.subjectCytochrome P450 2D6 (CYP2D6)
dc.subjectSelective serotonin re-uptake inhibitors (SSRIs)
dc.titleInteraction of terbinafine (anti-fungal agent) with perhexiline: a case report
dc.typeJournal article
pubs.publication-statusPublished

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