A genome-wide association meta-analysis identifies new childhood obesity loci

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dc.contributor.authorBradfield, J.
dc.contributor.authorTaal, H.
dc.contributor.authorTimpson, N.
dc.contributor.authorScherag, A.
dc.contributor.authorLecoeur, C.
dc.contributor.authorWarrington, N.
dc.contributor.authorHypponen, E.
dc.contributor.authorHolst, C.
dc.contributor.authorValcarcel, B.
dc.contributor.authorThiering, E.
dc.contributor.authorSalem, R.
dc.contributor.authorSchumacher, F.
dc.contributor.authorCousminer, D.
dc.contributor.authorSleiman, P.
dc.contributor.authorJianhua, Z.
dc.contributor.authorBerkowitz, R.
dc.contributor.authorVimaleswaran, K.
dc.contributor.authorIvonne, J.
dc.contributor.authorPennell, C.
dc.contributor.authorEvans, D.
dc.contributor.authoret al.
dc.date.issued2012
dc.description.abstractMultiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10−6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10−9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10−9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI.
dc.description.statementofresponsibilityJonathan P Bradfield ... Lyle J Palmer ... et al. for the Early Growth Genetics (EGG) Consortium
dc.identifier.citationNature Genetics, 2012; 44(5):526-531
dc.identifier.doi10.1038/ng.2247
dc.identifier.issn1061-4036
dc.identifier.issn1546-1718
dc.identifier.urihttp://hdl.handle.net/2440/88481
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/403981
dc.rights© 2012 Nature America, Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1038/ng.2247
dc.subjectEarly Growth Genetics Consortium
dc.subjectHumans
dc.subjectObesity
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Markers
dc.subjectBody Mass Index
dc.subjectCase-Control Studies
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAdolescent
dc.subjectAdult
dc.subjectGenome-Wide Association Study
dc.subjectYoung Adult
dc.subjectGenetic Loci
dc.titleA genome-wide association meta-analysis identifies new childhood obesity loci
dc.typeJournal article
pubs.publication-statusPublished

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