Basic concepts in population modeling, simulation, and model-based drug development. Part 2: introduction to pharmacokinetic modeling methods
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2013
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Mould, D.R.
Upton, R.N.
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Journal article
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CPT: Pharmacometrics and Systems Pharmacology, 2013; 2(4):1-4
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Population pharmacokinetic models are used to describe the time course of drug exposure in patients and to investigate sources of variability in patient exposure. They can be used to simulate alternative dose regimens, allowing for informed assessment of dose regimens before study conduct. This paper is the second in a three‐part series, providing an introduction into methods for developing and evaluating population pharmacokinetic models. Example model files are available in the
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<jats:bold>Supplementary Data</jats:bold>
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online.
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<jats:italic>CPT: Pharmacometrics & Systems Pharmacology</jats:italic>
(2013) 2, e38; doi:
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; advance online publication 17 April 2013
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Copyright 2013 The Authors. This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial-NoDerivs Licence, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. (http://creativecommons.org/licenses/by-nc-nd/3.0/)