Sleep apnea cardiovascular clinical trials-current status and steps forward: the International Collaboration of Sleep Apnea Cardiovascular Trialists

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dc.contributor.authorGottlieb, D.
dc.contributor.authorCraig, S.
dc.contributor.authorLorenzi-Filho, G.
dc.contributor.authorHeeley, E.
dc.contributor.authorRedline, S.
dc.contributor.authorMcEvoy, R.
dc.contributor.authorDuran-Cantolla, J.
dc.date.issued2013
dc.description.abstractSleep apnea is a common chronic disease that is associated with coronary heart disease, stroke, heart failure and mortality, although the ability of sleep apnea treatment to reduce cardiovascular morbidity and mortality has not been demonstrated. In contrast to patients seeking treatment in sleep disorders centers, as many as half of individuals with moderate to severe sleep apnea in the general population do not report excessive sleepiness; however, if treatment of sleep apnea were shown to reduce cardiovascular disease risk, this would provide a strong rationale for treatment of sleep apnea even in the absence of daytime sleepiness. This article summarizes the status of clinical trials evaluating the potential cardiovascular benefits of sleep apnea treatment and discusses the challenges of conducting such trials, and introduces the International Collaboration of Sleep Apnea Cardiovascular Trialists (INCOSACT), a clinical research collaboration formed to foster cardiovascular sleep research.
dc.description.statementofresponsibilityDaniel J. Gottlieb, Sonya E. Craig, Geraldo Lorenzi-Filho, Emma Heeley, Susan Redline, R. Doug McEvoy and Joaquín Durán-Cantolla
dc.identifier.citationSleep, 2013; 36(7):975-980
dc.identifier.doi10.5665/sleep.2790
dc.identifier.issn0161-8105
dc.identifier.issn1550-9109
dc.identifier.orcidMcEvoy, R. [0000-0002-5759-0094]
dc.identifier.urihttp://hdl.handle.net/2440/82310
dc.language.isoen
dc.publisherAmer Academy Sleep Medicine
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.5665/sleep.2790
dc.subjectcardiovascular disease
dc.subjectclinical trials
dc.subjectsleep apnea
dc.titleSleep apnea cardiovascular clinical trials-current status and steps forward: the International Collaboration of Sleep Apnea Cardiovascular Trialists
dc.typeJournal article
pubs.publication-statusPublished

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