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Systemic inflammatory indices predict tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer

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dc.contributor.authorLai, S.
dc.contributor.authorHuang, L.
dc.contributor.authorLuo, S.
dc.contributor.authorLiu, Z.
dc.contributor.authorDong, J.
dc.contributor.authorWang, L.
dc.contributor.authorKang, L.
dc.date.issued2020
dc.description.abstractSystemic inflammatory responses are associated with the prognosis of patients with colorectal cancer. However, the value in predicting tumor responses to neoadjuvant chemoradiotherapy (nCRT) remains to be elucidated. The current study aimed to investigate the association between systemic inflammatory indices and pathological complete response (pCR). The training and validation cohorts included 225 and 96 patients with locally advanced rectal cancer. The neutrophil‑to‑lymphocyte ratio (NLR) and platelet‑to‑lymphocyte ratio were recorded prior to nCRT and radical surgery. Univariate and multivariate analysis were used to investigate the association between systemic inflammatory indices and pCR. Systemic inflammatory indices prior to or following treatment had no significant association with pCR; however, the percentage change in NLR from pre‑nCRT to post‑nCRT was associated with a poor response, and a percentage change of >21.5% NLR (P=0.006; OR=0.413; 95% CI=0.22‑0.773) was a predictor of poor pCR. Therefore, in rectal cancer, the percentage change in NLR from pre‑ to post‑nCRT was found to be a predictor of poor pCR.
dc.identifier.citationOncology Letters, 2020; 20(3):2763-2770
dc.identifier.doi10.3892/ol.2020.11812
dc.identifier.issn1792-1074
dc.identifier.issn1792-1082
dc.identifier.urihttps://hdl.handle.net/11541.2/144581
dc.language.isoen
dc.publisherSpandidos Publications
dc.relation.fundingNHMRC 1158402
dc.rightsCopyright 2020 The author(s) This is an open access article distributed under the terms of Creative Commons Attribution License. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.source.urihttps://doi.org/10.3892/ol.2020.11812
dc.subjectcolorectal cancer
dc.subjectlocal advanced rectal cancer
dc.subjectneoadjuvant chemoradiotherapy
dc.titleSystemic inflammatory indices predict tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12205059170001831 13205059160001831 ol_20_3_2763_PDF.pdf
ror.mmsid9916432211401831

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