Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans

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dc.contributor.authorFeltrin, K.
dc.contributor.authorLittle, T.
dc.contributor.authorMeyer, J.
dc.contributor.authorHorowitz, M.
dc.contributor.authorRades, T.
dc.contributor.authorWishart, J.
dc.contributor.authorFeinle-Bisset, C.
dc.date.issued2007
dc.description.abstractAnimal studies suggest that the effects of fatty acids on gastric emptying and pancreatic secretion are both concentration and load dependent, while their suppressive effect on energy intake is only load dependent. We postulated that, in humans, the modulation of antropyloroduodenal pressurewaves, plasma cholecystokinin (CCK) and peptideYY(PYY) concentrations and energy intake by intraduodenal lauric acid, a fatty acid with 12 carbon atoms (‘C12’) would be load, but not concentration, dependent. Two groups of 12 healthy males were each studied on three separate occasions in double-blind randomized fashion. Antropyloroduodenal pressure waves, plasma CCK and PYY, and appetite perceptions were measured during intraduodenal infusions of C12 at (1) different loads of (i) 0.2, (ii) 0.3 and (iii) 0.4 kcal min−1 (all 56mM) for 90 min, and (2) different concentrations of (i) 40, (ii) 56 and (iii) 72mM (all 0.4 kcal min−1) for 60 min. Energy intake at a buffet meal consumed immediately following each infusion was quantified. Suppression of antral and duodenal pressure waves, stimulation of pyloric pressure waves, stimulation of plasma CCK and PYY, and suppression of energy intake, were related to the load of C12 administered (r >0.65, P <0.05). In contrast, there were no concentration-dependent effects of C12 on any of these parameters. In conclusion, in humans, the effects of intraduodenal C12 on antropyloroduodenal motility, plasma CCK and PYY and energy intake appear to be related to load, but not concentration, at least at the loads and concentrations evaluated.
dc.description.statementofresponsibilityKate L. Feltrin, Tanya J. Little, James H. Meyer, Michael Horowitz, Thomas Rades, JudithWishart and Christine Feinle-Bisset
dc.identifier.citationThe Journal of Physiology, 2007; 581(2):767-777
dc.identifier.doi10.1113/jphysiol.2007.129650
dc.identifier.issn0022-3751
dc.identifier.issn1469-7793
dc.identifier.orcidLittle, T. [0000-0001-9814-1036]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidRades, T. [0000-0002-7521-6020]
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]
dc.identifier.urihttp://hdl.handle.net/2440/42231
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.source.urihttp://www.blackwell-synergy.com/doi/pdf/10.1113/jphysiol.2007.129650
dc.subjectDuodenum
dc.subjectUpper Gastrointestinal Tract
dc.subjectPyloric Antrum
dc.subjectPylorus
dc.subjectHumans
dc.subjectCholecystokinin
dc.subjectPeptide YY
dc.subjectLauric Acids
dc.subjectInfusions, Parenteral
dc.subjectDouble-Blind Method
dc.subjectAppetite
dc.subjectEnergy Intake
dc.subjectGastrointestinal Motility
dc.subjectDose-Response Relationship, Drug
dc.subjectPressure
dc.subjectTime Factors
dc.subjectReference Values
dc.subjectAdult
dc.subjectMale
dc.titleEffects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans
dc.typeJournal article
pubs.publication-statusPublished

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