Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function

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dc.contributor.authorLarson-Meyer, D.
dc.contributor.authorNewcomer, B.
dc.contributor.authorHeilbronn, L.
dc.contributor.authorVolaufova, J.
dc.contributor.authorSmith, S.
dc.contributor.authorAlfonso, A.
dc.contributor.authorLefevre, M.
dc.contributor.authorRood, J.
dc.contributor.authorWilliamson, D.
dc.contributor.authorRavussin, E.
dc.contributor.authorDeLany, J.
dc.contributor.authorde Jonge, L.
dc.contributor.authorNguyen, T.
dc.contributor.authorMartin, C.
dc.contributor.authorMost, M.
dc.contributor.authorGreenway, F.
dc.contributor.authorYork-Crowe, E.
dc.contributor.authorAnton, S.
dc.contributor.authorChampagne, C.
dc.contributor.authorDahmer, B.
dc.contributor.authoret al.
dc.date.issued2008
dc.description.abstractOBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) and its association with insulin resistance are increasingly recognized as major health burdens. The main objectives of this study were to assess the relation between liver lipid content and serum lipids, markers of liver function and inflammation in healthy overweight subjects, and to determine whether caloric restriction (CR) (which improves insulin resistance) reduces liver lipids in association with these same measures. METHODS AND PROCEDURES: Forty-six white and black overweight men and women (BMI = 24.7–31.3 kg/m2) were randomized to "control (CO)" = 100% energy requirements; "CR" = 25% ; "caloric restriction and increased structured exercise (CR+EX)"= 12.5% CR + 12.5% increase in energy expenditure through exercise; or "low-calorie diet (LCD)" = 15% weight loss by liquid diet followed by weight-maintenance, for 6 months. Liver lipid content was assessed by magnetic resonance spectroscopy (MRS) and computed tomography (CT). Lipid concentrations, markers of liver function (alanine aminotransferase (ALT), alkaline phosphatase (ALK)), and whole-body inflammation (tumor necrosis factor- (TNF- ), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP)) were measured in fasting blood. RESULTS: At baseline, increased liver lipid content (by MRS) correlated (P < 0.05) with elevated fasting triglyceride (r = 0.52), ALT (r = 0.42), and hsCRP (r = 0.33) concentrations after adjusting for sex, race, and alcohol consumption. With CR, liver lipid content was significantly lowered by CR, CR+EX, and LCD (detected by MRS only). The reduction in liver lipid content, however, was not significantly correlated with the reduction in triglycerides (r = 0.26; P = 0.11) or with the changes in ALT, high-density lipoprotein (HDL)-cholesterol, or markers of whole-body inflammation. DISCUSSION: CR may be beneficial for reducing liver lipid and lowering triglycerides in overweight subjects without known NAFLD.
dc.description.statementofresponsibilityD. Enette Larson-Meyer, Bradley R. Newcomer, Leonie K. Heilbronn, Julia Volaufova, Steven R. Smith, Anthony J. Alfonso, Michael Lefevre, Jennifer C. Rood, Donald A. Williamson, Eric Ravussin and The Pennington CALERIE Team
dc.identifier.citationObesity, 2008; 16(6):1355-1362
dc.identifier.doi10.1038/oby.2008.201
dc.identifier.issn1930-7381
dc.identifier.issn1930-739X
dc.identifier.orcidHeilbronn, L. [0000-0003-2106-7303]
dc.identifier.urihttp://hdl.handle.net/2440/65900
dc.language.isoen
dc.publisherNorth Amer Assoc Study Obesity
dc.rights© 2008 The Obesity Society
dc.source.urihttps://doi.org/10.1038/oby.2008.201
dc.subjectPennington CALERIE Team
dc.subjectLiver
dc.subjectHumans
dc.subjectInsulin Resistance
dc.subjectInflammation
dc.subjectAlkaline Phosphatase
dc.subjectAlanine Transaminase
dc.subjectLipids
dc.subjectTriglycerides
dc.subjectTumor Necrosis Factor-alpha
dc.subjectC-Reactive Protein
dc.subjectInterleukin-6
dc.subjectCombined Modality Therapy
dc.subjectExercise
dc.subjectCaloric Restriction
dc.subjectCross-Sectional Studies
dc.subjectPilot Projects
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectOverweight
dc.subjectCholesterol, HDL
dc.titleEffect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function
dc.typeJournal article
pubs.publication-statusPublished

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